NUP93 - nucleoporin 93 Gene

中文名称：核孔蛋白 93

种属: Homo sapiens

同用名: NIC96

基因 ID: 9688 | 基因类型: protein coding

关于 NUP93

Cytogenetic location: 16q13 Genomic coordinates (GRCh38): 16:56,730,129-56,850,286 (from NCBI)

This gene has 21 transcripts (splice variants), 216 orthologues and is associated with 2 phenotypes. Broad expression in testis (RPKM 20.8), thyroid (RPKM 10.6) and 24 other tissues.

功能概要

核孔复合体是一个巨大的结构，延伸穿过核膜，形成调节细胞核和细胞质之间大分子流动的通道。核孔蛋白是真核细胞核孔复合体的主要成分。该基因编码一种核孔蛋白，该蛋白定位于孔的篮子和孔的中央门控通道的核入口。编码的蛋白质是半胱天冬酶半胱氨酸蛋白酶的靶标，在细胞凋亡引起的程序性细胞死亡中起着核心作用。可变剪接导致编码不同异构体的多个转录变体。[RefSeq 提供，2016 年 12 月]

The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. This gene encodes a nucleoporin protein that localizes both to the basket of the pore and to the nuclear entry of the central gated channel of the pore. The encoded protein is a target of Caspase cysteine proteases that play a central role in programmed cell death by Apoptosis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016]

NUP93 基因产物(3)

mRNA	Protein	Name
NM_001242795.2	NP_001229724.1	nuclear pore complex protein Nup93 isoform 2
NM_001242796.2	NP_001229725.1	nuclear pore complex protein Nup93 isoform 2
NM_014669.5	NP_055484.3	nuclear pore complex protein Nup93 isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	26878725	GOA
enables structural constituent of nuclear pore	IMP IMP: 通过突变表型推断	15229283	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in nuclear envelope organization	IDA IDA: 通过直接分析推断	26878725	GOA
involved in nuclear pore complex assembly	IDA IDA: 通过直接分析推断	26878725	GOA
involved in nuclear pore complex assembly	IMP IMP: 通过突变表型推断	15229283	GOA
involved in positive regulation of SMAD protein signal transduction	IDA IDA: 通过直接分析推断	26878725	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in nuclear envelope	IDA IDA: 通过直接分析推断	24315095	GOA
located in nuclear membrane	IDA IDA: 通过直接分析推断	15229283	GOA
located in nuclear periphery	IDA IDA: 通过直接分析推断	15229283	GOA
part of nuclear pore	IDA IDA: 通过直接分析推断	12802065	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NUP93 蛋白结构

Nic96

0
200
400
600
819 a.a.

蛋白主名

其他名称

nuclear pore complex protein Nup93

93 kDa nucleoporin

NUP93 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	NUP93	Q8N1F7	TMEM100	Homo sapiens	Q9NV29	Validated Y2H	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Nephrotic Syndrome, Type 12

NPHS12	Nephrotic Syndrome Type 12
Nephrotic Syndrome 12

Genetic Steroid-Resistant Nephrotic Syndrome

Familial Idiopathic Steroid-Resistant Nephrotic Syndrome	Genetic Srns
Hereditary Steroid-Resistant Nephrotic Syndrome	Familial Idiopathic Nephrotic Syndrome
Nephrotic Syndrome, Steroid-Resistant, Autosomal Recessive	Srn1

Nephrotic Syndrome

Finnish Congenital Nephrotic Syndrome	Ns - [Nephrotic Syndrome]
Nephrosis Syndrome	Nephrosis Nos
Glomerular Lesion Nephrosis

Focal Segmental Glomerulosclerosis

Familial Idiopathic Steroid-Resistant Nephrotic Syndrome	Focal Glomerulosclerosis
Fsgs	Segmental Glomerulosclerosis
Glomerulosclerosis, Focal Segmental	Fgs
Focal Glomerular Sclerosis	Familial Idiopathic Nephrotic Syndrome
Focal Sclerosis With Hyalinosis	Glomerulosclerosis, Focal
Glomerulosclerosis Focal	Glomerulosclerosis, Segmental, Focal
Focal Segmental Glomerulosclerosis, Not Otherwise Specified

Breast Juvenile Papillomatosis

Juvenile Papillomatosis Of The Breast

Marcus Gunn Phenomenon

Jaw-Winking Syndrome	Marcus-Gunn Syndrome
Jaw-Winking	Maxillopalpebral Synkinesis
Abnormal Innervation Syndrome Of Eyelid	Jaw-Blinking
Pterygoid-Levator Synkinesis	Familial Marcus Gunn Phenomenon
Marcus Gunn Syndrome	Mandibulo-Palpebral Synkinesis-Ptosis Syndrome
Marcus-Gunn Phenomenon

Cranioectodermal Dysplasia 4

CED4	Sensenbrenner Syndrome 4
Dysplasia, Cranioectodermal, Type 4

Galloway-Mowat Syndrome

Galloway Mowat Syndrome	Galloway Syndrome
Hiatal Hernia-Microcephaly-Nephrosis, Galloway Type	Microcephaly Nephrosis Syndrome
Microcephaly, Hiatal Hernia, And Nephrotic Syndrome	Nephrosis Neuronal Dysmigration Syndrome
Microcephaly-Hiatus Hernia-Nephrotic Syndrome	Nephrosis-Neuronal Dysmigration Syndrome

Frasier Syndrome

Achalasia-Addisonianism-Alacrima Syndrome

Allgrove Syndrome	Triple-A Syndrome
Achalasia-Addisonianism-Alacrimia Syndrome	Alacrima-Achalasia-Adrenal Insufficiency Neurologic Disorder
Triple A Syndrome	Aaa Syndrome
AAAS	Glucocorticoid Deficiency With Achalasia
Glucocorticoid Deficiency And Achalasia	Addisonian-Achalasia Syndrome
Hypoadrenalism With Achalasia	Alacrima-Achalasia-Addisonianism
Aaa	Acth-Resistant Adrenal Insufficiency, Achalasia And Alacrima
Achalasia Addisonianism Alacrimia Syndrome	Achalasia Alacrima Syndrome
Addisonian Achalasia Syndrome	Achalasia-Addisonian Syndrome
Achalasia-Alacrima Syndrome	2a Syndrome
3a Syndrome	4a Syndrome
Adrenal Insufficiency-Achalasia-Alacrima Syndrome	Double A Syndrome
Quaternary A Syndrome	Acth-Resistant Adrenal Insufficiency With Achalasia And Alacrima
Allgrove'S Syndrome	Adrenal Gland Hypofunction
Adrenal Cortical Hypofunction

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS09700	NUP93 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	NUP93	RGD	RGD:1311525
Mus musculus	NUP93	MGD	MGI:1919055
Bos taurus	NUP93	VGNC	VGNC:32366
Macaca mulatta	NUP93	VGNC	VGNC:75481
Felis catus	NUP93	VGNC	VGNC:63928
Canis familiaris	NUP93	VGNC	VGNC:44062

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

NUP93 - nucleoporin 93 Gene

关于 NUP93

功能概要

NUP93 基因产物(3)

NUP93 蛋白结构

NUP93 蛋白互作信息

关联疾病

直系同源

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NUP93 - nucleoporin 93 Gene

关于 NUP93

功能概要

NUP93 基因产物(3)

NUP93 蛋白结构

NUP93 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

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B

C

F

G

H

J

L

N

Q

S

T

X

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