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  4. OGN/Osteoglycin 蛋白, Mouse (HEK293, His)

OGN/Osteoglycin 蛋白, Mouse (HEK293, His)

目录号: HY-P702525
产品使用指南

OGN/骨甘氨酸蛋白与 TGF-β-1 或 TGF-β-2 协同调节骨形成。它与 TGF-β 的特定异构体协同相互作用，调节骨骼发育和重塑。这凸显了 OGN 在骨稳态中的重要性及其作为骨相关疾病治疗靶点的潜力。OGN/Osteoglycin 蛋白, Mouse (HEK293, His) 是重组的 OGN/骨甘蛋白，由 HEK293 表达，带有 C-6*His 标签。OGN/Osteoglycin 蛋白, Mouse (HEK293, His) 全长 279 个氨基酸。

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描述

OGN/Osteoglycin protein collaborates with TGF-beta-1 or TGF-beta-2 to regulate bone formation. It interacts synergistically with specific isoforms of TGF-beta, modulating bone development and remodeling. This highlights OGN's significance in bone homeostasis and its potential as a therapeutic target for bone-related conditions. OGN/Osteoglycin Protein, Mouse (HEK293, His) is the recombinant mouse-derived OGN/Osteoglycin protein, expressed by HEK293 , with C-6*His labeled tag. The total length of OGN/Osteoglycin Protein, Mouse (HEK293, His) is 279 a.a..
研究背景

OGN/骨甘氨酸蛋白作为关键调节剂，与 TGF-β-1 或 TGF-β-2 协同诱导骨形成。这意味着 OGN 通过与转化生长因子-β 的特定异构体协同相互作用，在调节骨发育和重塑过程中发挥着关键作用。OGN 和 TGF-β 信号通路之间精心策划的相互作用强调了其在控制骨稳态的复杂分子机制中的重要性，并强调了其作为骨形成和维持相关疾病的治疗靶点的潜力。
种属

Mouse
表达系统

HEK293
标签

C-6*His
蛋白编号

Q62000 (A20-F298)
基因 ID

18295
蛋白结构
N-term
OGN (A20-F298)
Accession # Q62000
6*His
C-term
同用名
Mimecan; DKFZp586P2421; KSPG25; mimecan proteoglycan; Mimecan; OGN; OIF; OIFOG; osteoglycin; Osteoinductive factor; SLRR3A; SLRR3Acorneal keratan sulfate proteoglycan
氨基酸序列

APQSQLDSHVNYEYATGNSEETKFSQDYEDKYLDGKSIKEKETMIIPDEKSLQLQKDEVIPSLPTKKENDEMPTCLLCVCLSGSVYCEEVDIDAVPPLPKESAYLYARFNKIKKLTAKDFADMPNLRRLDFTGNLIEDIEDGTFSKLSLLEELTLAENQLLRLPVLPPKLTLLNAKHNKIKSKGIKANTFKKLNKLSFLYLDHNDLESVPPNLPESLRVIHLQFNSISSLTDDTFCKANDTRYIRERIEEIRLEGNPIALGKHPNSFICLKRLPIGSYF

分子量

Approximately 44-45 kDa due to the glycosylation.
纯度

Greater than 95% as determined by reducing SDS-PAGE.
内毒素含量

<0.1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

OGN/Osteoglycin Protein, Mouse (HEK293, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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