OSM 蛋白, Human (HEK293, His-Avi)

OSM protein is a multifunctional growth regulator with dual functions of inhibiting tumor cell lines and stimulating the proliferation of AIDS-KS cells. It coordinates the production of cytokines, including IL-6, G-CSF, and GM-CSF, and binds to type I and type II OSM receptors, forming heterodimers with LIFR/IL6ST and OSMR/IL6ST, respectively. OSM Protein, Human (HEK293, His-Avi) is the recombinant human-derived OSM protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of OSM Protein, Human (HEK293, His-Avi) is 196 a.a., with molecular weight of 30-40 kDa.

GMP OSM 蛋白是一种多功能生长调节剂，对多种肿瘤细胞系的增殖具有双重抑制作用，对 AIDS-KS 细胞增殖具有刺激作用。值得注意的是，OSM 协调细胞因子产生的调节，包括内皮细胞的 IL-6、G-CSF 和 GM-CSF。这种多方面的生长调节剂既与 I 型 OSM 受体结合，形成由 LIFR 和 IL6ST 组成的异二聚体，又与 II 型 OSM 受体结合，形成由 OSMR 和 IL6ST 组成的异二聚体。除了其抗增殖和增殖作用之外，OSM 在胎儿肝细胞的成熟中发挥着至关重要的作用，对肝脏发育和再生做出了重大贡献。

Human LIF R, His Tag immobilized on CM5 Chip can bind Human OSM, His Tag with an affinity constant of 0.87 μM as determined in SPR assay (Biacore T200).

Human

HEK293

C-Avi;C-His

P13725 (A26-R221)

5008  [NCBI]

30-40 kDa

Greater than 95% as determined by Tris-Bis PAGE.

无菌粉末.

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Normally 5% trehalose is added as protectant before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.