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  3. PARM-1 蛋白, Human (HEK293, His)

PARM-1 蛋白, Human (HEK293, His)

目录号: HY-P73730
产品使用指南

PARM-1 蛋白是一种高度糖基化的粘蛋白样 1 型跨膜蛋白,主要位于质膜和内吞途径中。PARM-1 也是一种促增殖和抗凋亡糖蛋白,参与内质网 (ER) 应激反应,它存在于大多数人体组织中,尤其在心脏、肾脏和胎盘中高表达。PARM-1 可能调节 TLP1 表达和端粒酶活性,从而使某些前列腺细胞能够抵抗凋亡。PARM-1 蛋白, Human (HEK293, His) 是重组的 PARM-1 蛋白,由 HEK293 表达,带有 C-His 标签。

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描述

PARM-1 Protein is a highly glycosylated, mucin-like type 1 transmembrane protein primarily located at the plasma membrane and in the endocytic pathway. PARM-1 is also a pro-proliferative and anti-apoptotic glycoprotein involved in the endoplasmic reticulum (ER) stress response, and its presence in most human tissues with especially high expression in heart, kidney and placenta. PARM-1 may regulate TLP1 expression and telomerase activity, thus enabling certain prostatic cells to resist apoptosis. PARM-1 Protein, Human (HEK293, His) is the recombinant human-derived PARM-1 protein, expressed by HEK293 , with C-His labeled tag.

研究背景

前列腺雄激素调节粘蛋白样蛋白 1 (PARM-1) 是一种高度糖基化的粘蛋白样 1 型跨膜蛋白,主要位于质膜和内吞途径中。PARM-1 也是一种促增殖和抗凋亡糖蛋白,参与内质网 (ER) 应激反应,它存在于大多数人体组织中,尤其在心脏、肾脏和胎盘中高表达。PARM-1 通过充当黄体酮代谢的新型调节剂来促进排卵和/或黄体功能。PARM-1 可能调节 TLP1 表达和端粒酶活性,从而使某些前列腺细胞能够抵抗凋亡。此外,人 PARM-1在前列腺癌细胞系中的异位表达增加了细胞增殖,从而表明其在前列腺和前列腺癌的生理生物学中的作用[1][2][13][4]

种属

Human

表达系统

HEK293

标签

C-His

蛋白编号

AAH13294.1 (L21-S258)

基因 ID
蛋白结构
N-term
PARM-1 (L21-S258)
Accession # AAH13294.1
His
C-term
同用名
Prostate androgen-regulated mucin-like protein 1; PARM-1
分子量

Approximately 25.7 kDa

纯度

Greater than 85% as determined by reducing SDS-PAGE.

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料

PARM-1 Protein, Human (HEK293, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
PARM-1 Protein, Human (HEK293, His)
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