PD-L2 蛋白, Cynomolgus/Rhesus macaque (HEK293, C-His)

PD-L2 Protein is an immune checkpoint receptor ligand that binds to PD-1 to activate pathways that inhibit TCR/ BCR-mediated immune cell activation. PDCD1LG2 can inhibit T-cell proliferation and inflammatory cytokine production. The expression of PDCD1LG2 on mouse tumor cells inhibits cytotoxic T-cell-mediated immune responses and can be used as a biomarker or prognostic indicator. PD-L2 Protein, Cynomolgus/Rhesus macaque (HEK293, C-His) is the recombinant cynomolgus-derived PD-L2 protein, expressed by HEK293 , with C-His labeled tag.

程序性细胞死亡 1 配体 2 (PDCD1LG2) 是一种细胞表面受体，也称为 PD-L2、B7-DC 或 CD273。PDCD1LG2是一种免疫检查点受体配体，在适应性免疫反应中发挥负调节作用。PDCD1LG2 与 PD-1 结合，激活抑制 TCR/BCR 介导的免疫细胞激活的途径。PDCD1LG2在免疫耐受和自身免疫中发挥着重要作用，PD-L1 和 PDCD1LG2 都可以抑制 T 细胞增殖和炎症细胞因子的产生。阻断 PDCD1LG2 会加剧实验性自身免疫性脑脊髓炎。PDCD1LG2 触发小鼠树突状细胞产生 IL-12，从而导致 T 细胞激活。PDCD1LG2 Ig 治疗导致 T 辅助细胞增殖。小鼠肿瘤细胞上 PDCD1LG2 的表达可抑制细胞毒性 T 细胞介导的免疫反应，可作为生物标志物或预后指标^[1][2][3][4]。

Rhesus Macaque; Cynomolgus

HEK293

C-His

A0A2K5U5Z4/XP_005581839 (L20-T220)

102146227  [NCBI]

40-50 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.