2. 重组蛋白
  3. Enzymes & Regulators
  4. PDE1B 蛋白, Human (sf9, His-GST)

PDE1B 蛋白, Human (sf9, His-GST)

目录号: HY-P75960
产品使用指南

PDE1B 蛋白是一种环核苷酸磷酸二酯酶，对生理过程中重要的第二信使 cAMP 和 cGMP 显示出双重特异性。PDE1B 优选 cGMP 作为底物，微调细胞对环核苷酸信号传导的反应。其双重特异性强调了其在多种生理途径中的调节作用。PDE1B 蛋白, Human (sf9, His-GST) 是重组的 PDE1B 蛋白，由 Sf9 insect cells 表达，带有 N-His, N-GST 标签。PDE1B 蛋白, Human (sf9, His-GST) 全长 536 个氨基酸，分子量约为 ~75 kDa。

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100 μg   询价  

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描述

PDE1B protein, a cyclic nucleotide phosphodiesterase, displays dual specificity for cAMP and cGMP, essential second messengers in physiological processes. Preferring cGMP as a substrate, PDE1B fine-tunes cellular responses to cyclic nucleotide signaling. Its dual specificity underscores its regulatory role in diverse physiological pathways. PDE1B Protein, Human (sf9, His-GST) is the recombinant human-derived PDE1B protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. The total length of PDE1B Protein, Human (sf9, His-GST) is 536 a.a., with molecular weight of ~75 kDa.
研究背景

PDE1B 蛋白作为环核苷酸磷酸二酯酶发挥作用，对第二信使 cAMP 和 cGMP 具有双重特异性，这两者都是各种生理过程中的关键调节因子。这种酶表现出对 cGMP 作为底物的偏好，有助于其在调节环核苷酸介导的细胞内信号传导中发挥作用。PDE1B 的双重特异性强调了其在微调细胞对环核苷酸信号传导反应中的重要性，从而在多种生理途径中发挥调节作用。
种属

Human
表达系统

Sf9 insect cells
标签

N-His;N-GST
蛋白编号

Q01064 (M1-D536)
基因 ID
蛋白结构
N-term
His-GST
PDE1B (M1-D536)
Accession # Q01064
C-term
同用名
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B; Cam-PDE 1B; PDE1B1; PDES1B
分子量

Approximately 75 kDa
纯度

Greater than 90% as determined by reducing SDS-PAGE
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

PDE1B Protein, Human (sf9, His-GST) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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