2. Gene
  3. PDE1B - phosphodiesterase 1B Gene

PDE1B - phosphodiesterase 1B Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：磷酸二酯酶 1B

种属: Homo sapiens

同用名: PDE1B1; PDES1B; HEL-S-79p

基因 ID: 5153 | 基因类型: protein coding

关于 PDE1B

Cytogenetic location: 12q13.2 Genomic coordinates (GRCh38): 12:54,549,601-54,579,239 (from NCBI)

This gene has 9 transcripts (splice variants), 128 orthologues and 20 paralogues. Broad expression in brain (RPKM 8.5), fat (RPKM 6.8) and 19 other tissues.

功能概要

该基因编码的蛋白质属于环核苷酸磷酸二酯酶 (PDE) 家族和 PDE1 亚家族。 PDE1 家族的成员是钙调蛋白依赖性 PDE，由钙-钙调蛋白复合物刺激。此 PDE 对第二信使 cAMP 和 cGMP 具有双重特异性，并优先选择 cGMP 作为底物。 cAMP 和 cGMP 作为许多重要生理过程的关键调节剂发挥作用。已针对该基因描述了编码不同亚型的可变剪接转录物变体。[RefSeq 提供，2011 年 7 月]

The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE1 subfamily. Members of the PDE1 family are calmodulin-dependent PDEs that are stimulated by a calcium-calmodulin complex. This PDE has dual-specificity for the second messengers, cAMP and cGMP, with a preference for cGMP as a substrate. cAMP and cGMP function as key regulators of many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]

PDE1B 基因产物(6)

mRNA Protein Name
NM_000924.4 NP_000915.1 dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform 1
NM_001165975.3 NP_001159447.1 dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform 2
NM_001288768.2 NP_001275697.1 dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform 3
NM_001288769.2 NP_001275698.1 dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform 4
NM_001315534.2 NP_001302463.1 dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform 3
NM_001315535.2 NP_001302464.1 dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform 5
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables 3',5'-cyclic-AMP phosphodiesterase activity IDA
IDA: 通过直接分析推断
14687666 GOA
enables 3',5'-cyclic-AMP phosphodiesterase activity IMP
IMP: 通过突变表型推断
8855339 GOA
enables 3',5'-cyclic-GMP phosphodiesterase activity IDA
IDA: 通过直接分析推断
14687666 GOA
enables calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity IDA
IDA: 通过直接分析推断
9419816 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
21044950 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to granulocyte macrophage colony-stimulating factor stimulus IDA
IDA: 通过直接分析推断
14687666 GOA
involved in cellular response to macrophage colony-stimulating factor stimulus IDA
IDA: 通过直接分析推断
14687666 GOA
involved in monocyte differentiation IEP
IEP: 通过表达模式推断
14687666 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytosol IDA
IDA: 通过直接分析推断
8855339 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PDE1B 蛋白结构

PDEase_I_N

PDEase_I_N: 3'5'-cyclic nucleotide phosphodiesterase N-terminal (77 - 137)

PDEase_I

PDEase_I: 3'5'-cyclic nucleotide phosphodiesterase (222 - 450)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 536 a.a.
蛋白主名 其他名称

dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B

calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B

63 kDa Cam-PDE

PDE1B 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
PDE1B Q01064 POT1 Homo sapiens Q9NUX5
Pull Down
21044950
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 PDE1B 蛋白

目录号 产品名 蛋白编号 纯度
HY-P75960 PDE1B Protein, Human (sf9, His-GST) Q01064 (M1-D536) ≥95%

PDE1B 抗体

目录号 产品名 应用 反应物种
HY-P81808 PDE1B Antibody (YA1553) WB Human, Mouse, Rat

关联疾病

疾病名称 别名
Impotence

Erectile Dysfunction

Sexual Impotence

Erectile Dysfunction Adverse Event
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Clinical Phase
生物活性分子 (2)
目录号 产品名 作用方式
纯度 Phase
HY-12501A ITI-214 Inhibitor 99.19% Phase 2
HY-12501 ITI-214 free base Inhibitor ≥98.0% Phase 2
Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-101490 PDE1-IN-2 Inhibitor ≥98.0% 否
HY-136569 DSR-141562 Inhibitor 99.98% 否
HY-120741 PF-04822163 Inhibitor / 否
HY-147946 PDE1-IN-4 Inhibitor / 否
HY-RS10211 PDE1B Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus PDE1B VGNC VGNC:68753
Mus musculus PDE1B MGD MGI:97523
Canis familiaris PDE1B VGNC VGNC:44349
Macaca mulatta PDE1B VGNC VGNC:75910
Rattus norvegicus PDE1B RGD RGD:3278
Bos taurus PDE1B VGNC VGNC:32672
Others PDE1B NCBI
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