2. Metabolic Enzyme/Protease
  3. Phosphodiesterase (PDE)
  4. PF-04822163

PF-04822163 是一种具有口服活性、选择性和血脑屏障透过性的 PDE1 抑制剂，其对 PDE1A、PDE1B 和PDE1C 的 IC50 值分别为 2 nM、2.4 nM 和 7 nM。PF-04822163 可以用于注意力缺陷多动障碍或帕金森病的研究。

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PF-04822163 Chemical Structure

PF-04822163 Chemical Structure

CAS No. : 1798334-07-2

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PF-04822163 相关抗体

Top Publications Citing Use of Products

查看 Phosphodiesterase (PDE) 亚型特异性产品:

查看所有亚型
PDE1 PDE2 PDE3 PDE4 PDE5 PDE6 PDE7 PDE9 PDE10 PDE11 PDE12 PDE8 Autotaxin

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PF-04822163 is an orally active, selective, and blood-brain barrier permeable PDE1 inhibitor with IC50 values of 2 nM, 2.4 nM, and 7 nM for PDE1A, PDE1B, and PDE1C respectively. PF-04822163 can be used in the research of attention deficit hyperactivity disorder or Parkinson's disease[1].

IC50 & Target

PDE1A

2 nM (IC50)

PDE1B

2.4 nM (IC50)

PDE1C

7 nM (IC50)

PDE2A

5895 nM (IC50)

PDE3A

>30000 nM (IC50)

PDE4D3

7620 nM (IC50)

PDE5A1

>30000 nM (IC50)

PDE7B

>29800 nM (IC50)

PDE9A1

>30000 nM (IC50)

PDE10A1

252 nM (IC50)

PDE11A4

8257 nM (IC50)

体内研究
(In Vivo)

PF-04822163 (10 mg/kg; 口服; 单剂量) 在 0.5 h 时大鼠血浆中的 Tmax 为 274 ng/mL，终末半衰期为 5.5 h，且具有血脑屏障透过性[1]。

在大鼠药代动力学分析[1]

species route dose Tmax(h) t1/2(h) fu B/P CSF/Pu
rat p.o. 10 mg/kg 0.5 - 0.028 3.4 1.7

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

340.80

Formula

C19H17ClN2O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PF-04822163 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PF-048221631798334-07-2PF04822163PF 04822163Phosphodiesterase (PDE)blood-brain barrierattention deficit hyperactivity disorderParkinson's diseaseInhibitorinhibitorinhibit

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产品名称：
PF-04822163
目录号：
HY-120741
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