PDYN 蛋白, Human (HEK293, His)

The PDYN protein, or prodynorphin, regulates Leu-enkephalins, mimicking opiate drug effects and impacting pain perception and stress responses. Dynorphin peptides, like Dynorphin A(1-13), uniquely regulate the kappa opioid receptor, with A(1-13) being exceptionally potent—700 times stronger than Leu-enkephalin—displaying typical opioid activity. PDYN Protein, Human (HEK293, His) is the recombinant human-derived PDYN protein, expressed by HEK293 , with C-6*His labeled tag. The total length of PDYN Protein, Human (HEK293, His) is 234 a.a., with molecular weight of ~35.0 kDa.

PDYN 蛋白也称为强啡肽原，与亮氨酸脑啡肽相关，后者与阿片类药物竞争并模仿阿片类药物的作用。这些肽在各种生理功能中发挥着关键作用，包括疼痛感知和压力反应。此外，强啡肽，例如强啡肽 A(1-13)，对 kappa 阿片受体表现出差异性调节。值得注意的是，强啡肽 A(1-13) 表现出典型的阿片类药物活性，并且效力明显更强，比亮氨酸脑啡肽强 700 倍。

Human

HEK293

C-6*His

P01213 (D21-A254)

5173  [NCBI]

DCLSRCSLCAVKTQDGPKPINPLICSLQCQAALLPSEEWERCQSFLSFFTPSTLGLNDKEDLGSKSVGEGPYSELAKLSGSFLKELEKSKFLPSISTKENTLSKSLEEKLRGLSDGFREGAESELMRDAQLNDGAMETGTLYLAEEDPKEQVKRYGGFLRKYPKRSSEVAGEGDGDSMGHEDLYKRYGGFLRRIRPKLKWDNQKRYGGFLRRQFKVVTRSQEDPNAYSGELFDA

Approximately 35.0 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.