Pentraxin 2/SAP 蛋白, Human (HEK293, His)

Pentraxin 2/SAP protein, a member of the pentraxin family, promotes innate immunity by recognizing pathogens and promoting their clearance. This soluble pattern recognition receptor is involved in multiple inflammatory processes, including complement activation, opsonization, and immune response regulation. Pentraxin 2/SAP Protein, Human (HEK293, His) is the recombinant human-derived Pentraxin 2/SAP protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Pentraxin 2/SAP Protein, Human (HEK293, His) is 204 a.a., with molecular weight of ~30.0 kDa.

CLIC2/XAP121 蛋白具有插入膜的能力，形成氯离子通道，其活性依赖于 pH 值。膜插入过程似乎受到氧化还原条件的调节，主要发生在氧化条件下。值得注意的是，CLIC2/XAP121 在调节 RYR2 活性中发挥调节作用，最终抑制钙内流。该蛋白作为单体发挥作用，并与 TRAPPC2 和 RYR2 相互作用，表明其在复杂的细胞过程中具有潜在作用。

Human

HEK293

C-6*His

P02743 (H20-V223)

325  [NCBI]

HTDLSGKVFVFPRESVTDHVNLITPLEKPLQNFTLCFRAYSDLSRAYSLFSYNTQGRDNELLVYKERVGEYSLYIGRHKVTSKVIEKFPAPVHICVSWESSSGIAEFWINGTPLVKKGLRQGYFVEAQPKIVLGQEQDSYGGKFDRSQSFVGEIGDLYMWDSVLPPENILSAYQGTPLPANILDWQALNYEIRGYVIIKPLVWV

Approximately 30.0 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US;may vary elsewhere.