Pentraxin 3/TSG-14 蛋白, Human (HEK293, His)

RGS5 Protein is a protein that plays a crucial role in the regulation of G-protein coupled receptor signaling. It is involved in modulating cellular processes such as vasoconstriction and blood pressure regulation. Dysregulation of RGS5 Protein has been associated with various diseases, including hypertension and cardiovascular disorders. Targeting RGS5 Protein may offer potential therapeutic interventions in these conditions by restoring normal G-protein signaling and maintaining vascular homeostasis. Pentraxin 3/TSG-14 Protein, Human (HEK293, His) is the recombinant human-derived Pentraxin 3/TSG-14 protein, expressed by HEK293 , with C-10*His labeled tag and with natural variants A48D mutation. The total length of Pentraxin 3/TSG-14 Protein, Human (HEK293, His) is 364 a.a., with molecular weight of 44-50 kDa.

Pentraxin 3/TSG-14 蛋白是 pentraxin 蛋白家族的成员，由该基因编码。其表达是由炎症细胞因子响应炎症刺激而诱导的，特别是在各种间充质和上皮细胞类型中，包括内皮细胞和单核吞噬细胞。这种蛋白质在促进纤维细胞分化中发挥着至关重要的作用，并积极参与调节炎症和补体激活。此外，它还有助于血管生成和组织重塑。值得注意的是，Pentraxin 3/TSG-14 可作为多种炎症状况的生物标志物，反映了其潜在的临床意义。该基因表现出偏向表达，在骨髓 (RPKM 32.2)、阑尾 (RPKM 24.8) 和其他六个组织中表达水平升高，突出了其在多个器官的各种生理环境中的特定参与。

Immobilized Anti-TSG-14 at 1 μg/mL (100 μL/well) can bind TSG-14. The ED₅₀ for this effect is 0.04374 μg/mL.

• 
  Immobilized Anti-TSG-14 at 1 μg/mL (100 μL/well) can bind TSG-14 , The ED₅₀ for this effect is 0.04374 μg/mL.

Human

HEK293

C-10*His

NP_002843.2 (E18-S381, with natural variants A48D)

5806  [NCBI]

ENSDDYDLMYVNLDNEIDNGLHPTEDPTPCDCGQEHSEWDKLFIMLENSQMRERMLLQATDDVLRGELQRLREELGRLAESLARPCAPGAPAEARLTSALDELLQATRDAGRRLARMEGAEAQRPEEAGRALAAVLEELRQTRADLHAVQGWAARSWLPAGCETAILFPMRSKKIFGSVHPVRPMRLESFSACIWVKATDVLNKTILFSYGTKRNPYEIQLYLSYQSIVFVVGGEENKLVAEAMVSLGRWTHLCGTWNSEEGLTSLWVNGELAATTVEMATGHIVPEGGILQIGQEKNGCCVGGGFDETLAFSGRLTGFNIWDSVLSNEEIRETGGAESCHIRGNIVGWGVTEIQPHGGAQYVS

44-50 kDa

• 
  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization or 20 mM PB, 150 mM NaCl, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.