PGD2 Synthase/PTGDS 蛋白, Rat (HEK293, His)

The PGD2 synthase/PTGDS protein converts PGH2 to PGD2, which regulates smooth muscle and inhibits platelet aggregation.It affects central nervous system functions including sedation, NREM sleep, and potential anti-apoptotic effects on oligodendrocytes.PGD2 Synthase/PTGDS Protein, Rat (HEK293, His) is the recombinant rat-derived PGD2 Synthase/PTGDS protein, expressed by HEK293 , with C-His, C-6*His labeled tag.

PGD2 合酶，也称为 PTGDS 蛋白，是多种生理过程中的关键酶促因子。它催化 PGH2 转化为 PGD2，PGD2 是平滑肌收缩/松弛所必需的前列腺素，也是血小板聚集的有效抑制剂。除了其血管功能外，PTGDS 还复杂地参与各种中枢神经系统 (CNS) 活动，包括镇静、NREM 睡眠和 PGE2 诱导的异常性疼痛，并可能在少突胶质细胞中发挥抗凋亡作用。该蛋白质表现出广泛的底物结合能力，与胆绿素、胆红素、视黄醛、视黄酸和甲状腺激素等小非底物亲脂性分子相互作用，可能充当有害疏水分子的清除剂，并充当分泌性视黄醇和甲状腺激素运输者。PTGDS 参与血液屏障的形成和维持，包括血脑、血视网膜、血-房水和血-睾丸屏障，突出了其在屏障功能中的重要性。此外，它在中枢神经系统和男性生殖系统的成熟和维持中发挥着关键作用。此外，PTGDS 参与 PLA2G3 依赖性肥大细胞成熟，其中未成熟肥大细胞分泌的 PLA2G3 在 PTGDS 上游发挥作用，合成 PGD2。这反过来又通过 PTGDR 促进肥大细胞成熟和脱颗粒，表明它参与免疫反应和细胞成熟。

Rat

HEK293

C-His;C-6*His

P22057/NP_037147.1 (Q25-E189)

25526  [NCBI]

QGHDTVQPNFQQDKFLGRWYSAGLASNSSWFREKKELLFMCQTVVAPSTEGGLNLTSTFLRKNQCETKVMVLQPAGVPGQYTYNSPHWGSFHSLSVVETDYDEYAFLFSKGTKGPGQDFRMATLYSRAQLLKEELKEKFITFSKDQGLTEEDIVFLPQPDKCIQE

Approximately 26-29 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.