PILR-alpha 蛋白, Human (178a.a, HEK293, Fc)

PILR-α is a member of the paired receptor family and functions as an inhibitory signaling receptor in immune regulation. It inhibits signal transduction by recruiting the phosphatases PTPN6/SHP-1 and PTPN11/SHP-2, blocking the phosphorylation of key signaling molecules. PILR-alpha Protein, Human (178a.a, HEK293, Fc) is the recombinant human-derived PILR-alpha protein, expressed by HEK293 , with C-hFc labeled tag.

PILR-α 属于配对受体家族，作为细胞信号传导抑制受体在免疫系统调节中发挥作用。据推测，该受体通过其 SH2 结构域募集细胞质磷酸酶（如 PTPN6/SHP-1 和 PTPN11/SHP-2）来发挥其抑制作用，通过关键信号分子的去磷酸化导致信号转导阻断。此外，PILR-α 作为 PIANP 的受体，在微生物感染的条件下，作为单纯疱疹病毒 1 的进入辅助受体。它参与这些分子相互作用，凸显了它在免疫调节和对病原体的细胞反应中的多功能参与。

Human

HEK293

C-hFc

Q9UKJ1-1 (Q20-A197)

29992  [NCBI]

QPSGSTGSGPSYLYGVTQPKHLSASMGGSVEIPFSFYYPWELATAPDVRISWRRGHFHRQSFYSTRPPSIHKDYVNRLFLNWTEGQKSGFLRISNLQKQDQSVYFCRVELDTRSSGRQQWQSIEGTKLSITQAVTTTTQRPSSMTTTWRLSSTTTTTGLRVTQGKRRSDSWHISLETA

60-70 kDa

Greater than 95% as determined by Tris-Bis PAGE.

无菌粉末.

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.