PILRA - paired immunoglobin like type 2 receptor alpha Gene

中文名称：配对免疫球蛋白样 2 型受体 α

种属: Homo sapiens

同用名: FDF03

关于 PILRA

功能概要

细胞信号通路依赖于激活和抑制过程之间的动态相互作用。 SHP-1 介导的蛋白质酪氨酸残基去磷酸化是调节多种细胞信号通路的核心。两种类型的抑制性受体超家族成员是免疫受体酪氨酸抑制基序 (ITIM) 携带受体及其非 ITIM 激活对应物。通过 SHP-1 控制细胞信号被认为是通过 PILRalpha 介导的抑制和 PILRbeta 介导的激活之间的平衡发生的。这些成对的免疫球蛋白样受体基因位于 7 号染色体上的串联头尾方向。该特定基因编码受体对中携带 ITIM 的成员，其发挥抑制作用。已在该位点观察到可变剪接，并描述了三个变体，每个变体编码不同的亚型。[RefSeq 提供，2008 年 7 月]

Cell signaling pathways rely on a dynamic interaction between activating and inhibiting processes. SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILRbeta-mediated activation. These paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This particular gene encodes the ITIM-bearing member of the receptor pair, which functions in the inhibitory role. Alternative splicing has been observed at this locus and three variants, each encoding a distinct isoform, are described. [provided by RefSeq, Jul 2008]