2. 重组蛋白
  3. Receptor Proteins
  4. PILR-alpha 蛋白, Human (HEK293, Fc)

PILR-alpha 蛋白, Human (HEK293, Fc)

目录号: HY-P77141
产品使用指南

配对免疫球蛋白样 2 型受体 α (PILRA) 是一种免疫受体酪氨酸基抑制基序 (ITIM) 成员携带的配对受体，由高度相关的激活受体和抑制受体组成，广泛参与免疫系统的调节，是一种细胞信号抑制受体，通过配体的 SH2 结构域募集细胞质磷酸酶，通过信号分子的去磷酸化阻断 SH1 等信号转导。PILR-alpha 蛋白, Human (HEK293, Fc) 是重组的 PILR-α 蛋白，由 HEK293 表达，带有 C-hFc 标签。

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描述

Paired immunoglobulin-like type 2 receptor alpha (PILRA) is a immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing member of the paired receptor which consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRA is thought to act as a cellular signaling inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction such as SH1 through dephosphorylation of signaling molecules. PILR-alpha Protein, Human (HEK293, Fc) is the recombinant human-derived PILR-alpha protein, expressed by HEK293 , with C-hFc labeled tag.
研究背景

配对免疫球蛋白样 2 型受体 α (PILRA) 是一种免疫受体酪氨酸基抑制基序 (ITIM) 成员携带的配对受体，由高度相关的激活受体和抑制受体组成，广泛参与免疫系统的调节。PILRA 被认为是一种细胞信号抑制受体，通过配体的 SH2 结构域募集细胞质磷酸酶，如 PTPN6/SHP-1 和 PTPN11/SHP-2，通过信号分子的去磷酸化阻断信号转导，而 SHP-1 介导的蛋白酪氨酸残基的去磷酸化是调节几种细胞信号通路的核心。PLPRA 是 PIANP 的受体，也是单纯疱疹病毒 1 的进入共受体[1][2][3]。
种属

Human
表达系统

HEK293
标签

C-hFc
蛋白编号

AAH17812 (Q20-D226)
基因 ID
蛋白结构
N-term
PILR-alpha (Q20-D226)
Accession # AAH17812
hFc
C-term
同用名
Paired immunoglobulin-like type 2 receptor alpha; Cell surface receptor FDF03; PILRA
分子量

Approximately 58&37 kDa
纯度

Greater than 95% as determined by reducing SDS-PAGE
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

PILR-alpha Protein, Human (HEK293, Fc) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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目录号：
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