PILR-beta 蛋白, Mouse (HEK293, Fc)

The PILR-β protein is a paired immune system modulator and is considered a signal-activated receptor that associates with cell surface ITAM adapters such as DAP12. It interacts with CD99 and may help natural killer cells recognize target cells and activate dendritic cells. PILR-beta Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived PILR-beta protein, expressed by HEK293 , with C-hFc labeled tag. The total length of PILR-beta Protein, Mouse (HEK293, Fc) is 165 a.a., with molecular weight of 55-60 kDa.

PILR-β 蛋白是免疫系统调节中不可或缺的配对受体的成员，被认为是一种细胞信号传导激活受体，与细胞表面上带有 ITAM 的接头分子形成关联。该蛋白被认为与 DAP12 相互作用，并作为 CD99 的受体发挥作用，可能有助于自然杀伤细胞识别靶细胞并参与树突状细胞的激活。观察到的与 CD99 的相互作用以及与 DAP12 的可能关联强调了 PILR-beta 在细胞信号传导途径中的作用，强调了其对免疫反应和细胞识别机制的潜在影响。

Immobilized PILR-beta at 2 μg/mL (100 μL/well) can bind Biotinylated CD99. The ED₅₀ for this effect is 2.353 µg/mL.

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  Immobilized PILR-beta at 2 μg/mL (100 μL/well) can bind Biotinylated CD99 . The ED₅₀ for this effect is 2.353 µg/mL.

Mouse

HEK293

C-hFc

Q2YFS2 (G29-G193)

170741  [NCBI]

GNSERYNRKNGFGVNQPERCSGVQGGSIDIPFSFYFPWKLAKDPQMSIAWKWKDFHGEVIYNSSLPFIHEHFKGRLILNWTQGQTSGVLRILNLKESDQAQYFSRVNLQSTEGMKLWQSIPGTQLNVTQALNTTMRSPFIVTSEFTTAGLEHTSDQRNPSLMNLG

Approximately 50-70 kDa due to the glycosylation

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  Greater than 90% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.