PLAU/uPA 蛋白, Mouse (Biotinylated, HEK293, His-Avi)

PLAU or urokinase-type plasminogen activator (uPA) critically initiates fibrinolysis by cleaving plasminogen to form active plasmin.This enzymatic conversion is critical for regulating clot dissolution and tissue remodeling.PLAU/uPA Protein, Mouse (Biotinylated, HEK293, His-Avi) is the recombinant mouse-derived PLAU/uPA protein, expressed by HEK293 , with C-Avi, C-His labeled tag.

PLAU，也称为尿激酶型纤溶酶原激活剂（uPA），通过特异性裂解酶原纤溶酶原生成活性酶纤溶酶，在纤维蛋白溶解中发挥至关重要的作用。这种酶促转化是调节血凝块溶解和组织重塑的关键步骤。PLAU 激活纤溶酶的能力启动一系列蛋白水解事件，有助于纤维蛋白凝块和细胞外基质成分的分解。这一过程对于各种生理功能至关重要，包括伤口愈合、组织修复和血栓溶解。

Human uPAR, hFc Tag captured on CM5 Chip via Protein A can bind Biotinylated Mouse PLAU, His-Avi Tag with an affinity constant of 8.05 μM as determined in SPR assay (Biacore T200).

Mouse

HEK293

C-Avi;C-His

P06869 (G21-F433)

18792  [NCBI]

GSVLGAPDESNCGCQNGGVCVSYKYFSRIRRCSCPRKFQGEHCEIDASKTCYHGNGDSYRGKANTDTKGRPCLAWNAPAVLQKPYNAHRPDAISLGLGKHNYCRNPDNQKRPWCYVQIGLRQFVQECMVHDCSLSKKPSSSVDQQGFQCGQKALRPRFKIVGGEFTEVENQPWFAAIYQKNKGGSPPSFKCGGSLISPCWVASAAHCFIQLPKKENYVVYLGQSKESSYNPGEMKFEVEQLILHEYYREDSLAYHNDIALLKIRTSTGQCAQPSRSIQTICLPPRFTDAPFGSDCEITGFGKESESDYLYPKNLKMSVVKLVSHEQCMQPHYYGSEINYKMLCAADPEWKTDSCKGDSGGPLICNIEGRPTLSGIVSWGRGCAEKNKPGVYTRVSHFLDWIQSHIGEEKGLAF

30-35 kDa

Greater than 95% as determined by Tris-Bis PAGE.

无菌粉末.

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Normally 8% trehalose is added as protectant before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.