1. Gene
  2. Plau - plasminogen activator, urokinase Gene

Plau - plasminogen activator, urokinase Gene

种属: Mus musculus

同用名: uPA; u-PA

基因 ID: 18792 | 基因类型: protein coding

关于 Plau

功能概要

Predicted to enable serine-type endopeptidase activity. Acts upstream of or within several processes, including fibrinolysis; response to hypoxia; and smooth muscle cell migration. Predicted to be located in cell surface and membrane. Predicted to be active in extracellular space. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; integumental system; and trophectoderm. Used to study Alzheimer's disease; fatty liver disease; and hepatocellular carcinoma. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease (multiple); Quebec platelet disorder; end stage renal disease; lung disease (multiple); and mitral valve prolapse. Orthologous to human PLAU (plasminogen activator, urokinase). [provided by Alliance of Genome Resources, Apr 2022]

Plau 基因产物(1)

mRNA Protein Name
NM_008873.3 NP_032899.1 urokinase-type plasminogen activator precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
25168896 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within fibrinolysis IMP
IMP: 通过突变表型推断
9733098 MGI
acts upstream of or within regulation of cell population proliferation IGI
IGI: 通过遗传相互作用推断
17893885 MGI
acts upstream of or within response to hypoxia IMP
IMP: 通过突变表型推断
17382917 MGI
acts upstream of or within smooth muscle cell migration IMP
IMP: 通过突变表型推断
17382917 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of serine-type endopeptidase complex IPI
IPI: 通过物理相互作用推断
20133942 MGI
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断
蛋白主名 其他名称

urokinase-type plasminogen activator

U-plasminogen activator

重组 Plau 蛋白

目录号 产品名 蛋白编号 纯度
HY-P78017 PLAU/uPA Protein, Mouse (HEK293, C-His-Avi) P06869 (G21-F433) ≥95%
HY-P78018 PLAU/uPA Protein, Mouse (Biotinylated, HEK293, His-Avi) P06869 (G21-F433) ≥95%

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Plau NCBI NCBI:5328
Macaca fascicularis Plau NCBI NCBI:102135886
Rattus norvegicus Plau NCBI NCBI:25619