1. 重组蛋白
  2. Others
  3. Plexin B1 蛋白, Human (HEK293, mFc)

Plexin B1 蛋白, Human (HEK293, mFc)

目录号: HY-P700428
产品使用指南

Plexin B1 蛋白是 SEMA4D 的受体,对 GABA 能和抑制性突触发育具有至关重要的影响。它激活 RHOA,导致肌动蛋白细胞骨架变化,影响轴突引导、侵袭性生长和细胞迁移。作为 PLXNB2 的单体或异二聚体,Plexin B1 结合激活的 RAC1 并与各种蛋白质相互作用。它与 SEMA4D 的相互作用强调了它在细胞信号通路和突触发育中的复杂参与。Plexin B1 蛋白, Human (HEK293, mFc) 是重组的 Plexin B1 蛋白,由 HEK293 表达,带有 N-mFc 标签。Plexin B1 蛋白, Human (HEK293, mFc) 全长 516 个氨基酸,分子量为 83.2 kDa。

MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

SPR 检测服务   重组蛋白定制服务

1.  客户无需承担相应的运输费用。

2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

规格 是否有货
50 μg   询价  
100 μg   询价  

* Please select Quantity before adding items.

  • 生物活性

  • 技术参数

  • 产品性质

  • 产品资料

描述

Plexin B1 Protein, a receptor for SEMA4D, crucially influences GABAergic and inhibitory synapse development. It activates RHOA, leading to actin cytoskeleton changes, impacting axon guidance, invasive growth, and cell migration. As a monomer or heterodimer with PLXNB2, Plexin B1 binds activated RAC1 and interacts with various proteins. Its interaction with SEMA4D emphasizes its intricate involvement in cellular signaling pathways and synaptic development. Plexin B1 Protein, Human (HEK293, mFc) is the recombinant human-derived Plexin B1 protein, expressed by HEK293, with N-mFc labeled tag. The total length of Plexin B1 Protein, Human (HEK293, mFc) is 516 a.a., with molecular weight of 83.2 kDa.

研究背景

Plexin B1 蛋白作为 SEMA4D 的受体,在 GABA 能突触发育和介导 SEMA4A 和 SEMA4D 依赖性抑制性突触发育中发挥关键作用。此外,它还参与 RHOA 激活和肌动蛋白细胞骨架的后续变化,有助于轴突引导、侵袭性生长和细胞迁移。它以单体存在,并在蛋白水解加工后与PLXNB2形成异二聚体。Plexin B1 与激活的 RAC1 结合,并与多种蛋白质相互作用,包括 PLXNA1、ARHGEF11、ARHGEF12、ERBB2、MET、MST1R、RRAS、RHOD、RND1、NRP1 和 NRP2。与 SEMA4D 的相互作用促进细胞质配体的结合,强调其在细胞信号传导途径和突触发育中的复杂参与。

种属

Human

表达系统

HEK293

标签

N-mFc

蛋白编号

O43157 (L20-Q535)

基因 ID
蛋白结构
N-term
mFc
Plexin B1 (L20-Q535)
Accession # O43157
C-term
同用名
Plexin-B1; PLXNB1; Semaphorin receptor SEP; KIAA0407; PLXN5; SEP
氨基酸序列

LQPLPPTAFTPNGTYLQHLARDPTSGTLYLGATNFLFQLSPGLQLEATVSTGPVLDSRDCLPPVMPDECPQAQPTNNPNQLLLVSPGALVVCGSVHQGVCEQRRLGQLEQLLLRPERPGDTQYVAANDPAVSTVGLVAQGLAGEPLLFVGRGYTSRGVGGGIPPITTRALWPPDPQAAFSYEETAKLAVGRLSEYSHHFVSAFARGASAYFLFLRRDLQAQSRAFRAYVSRVCLRDQHYYSYVELPLACEGGRYGLIQAAAVATSREVAHGEVLFAAFSSAAPPTVGRPPSAAAGASGASALCAFPLDEVDRLANRTRDACYTREGRAEDGTEVAYIEYDVNSDCAQLPVDTLDAYPCGSDHTPSPMASRVPLEATPILEWPGIQLTAVAVTMEDGHTIAFLGDSQGQLHRVYLGPGSDGHPYSTQSIQQGSAVSRDLTFDGTFEHLYVMTQSTLLKVPVASCAQHLDCASCLAHRDPYCGWCVLLGRCSRRSECSRGQGPEQWLWSFQPELGCLQ

分子量

83.2 kDa

纯度

Greater than 95% as determined by reducing SDS-PAGE.

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料

Plexin B1 Protein, Human (HEK293, mFc) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称:

 

* 需求量:

* 客户姓名:

 

* Email:

* 电话:

 

* 公司或机构名称:

   留言给我们:

Bulk Inquiry

Inquiry Information

产品名称:
Plexin B1 Protein, Human (HEK293, mFc)
目录号:
HY-P700428
需求量: