PMVK 蛋白, Human (His)

PMVK proteins play a key role in cellular metabolism by catalyzing the reversible ATP-dependent phosphorylation of mevalonate 5-phosphate, leading to the production of mevalonate diphosphate and ADP. This enzymatic activity represents a key step in the mevalonate-mediated biosynthesis of isopentenyl diphosphate, a precursor for the synthesis of various polyisoprene metabolites. PMVK Protein, Human (His) is the recombinant human-derived PMVK protein, expressed by E. coli , with N-6*His labeled tag. The total length of PMVK Protein, Human (His) is 192 a.a., with molecular weight of ~26.0 kDa.

PMVK（磷酸羟戊酸激酶）蛋白是一种催化甲羟戊酸途径中关键步骤的酶，对于异戊烯基二磷酸和各种聚异戊二烯代谢物的生物合成至关重要。具体来说，PMVK 促进甲羟戊酸 5-磷酸的可逆 ATP 依赖性磷酸化，生成甲羟戊酸二磷酸和 ADP。这种酶活性对于类异戊二烯的产生至关重要，类异戊二烯是甾醇、多醇和泛醌等重要细胞成分的前体。PMVK 参与的甲羟戊酸途径在多种生物过程中发挥着核心作用，包括胆固醇合成和细胞膜完整性的调节。了解 PMVK 的功能有助于深入了解类异戊二烯代谢的调节及其对各种细胞功能的影响。参考资料：所提供的信息基于截至 2022 年 1 月的一般知识，未引用具体参考资料。

Human

E. coli

N-6*His

Q15126 (M1-L192)

10654  [NCBI]

MAPLGGAPRLVLLFSGKRKSGKDFVTEALQSRLGADVCAVLRLSGPLKEQYAQEHGLNFQRLLDTSTYKEAFRKDMIRWGEEKRQADPGFFCRKIVEGISQPIWLVSDTRRVSDIQWFREAYGAVTQTVRVVALEQSRQQRGWVFTPGVDDAESECGLDNFGDFDWVIENHGVEQRLEEQLENLIEFIRSRL

Approximately 26.0 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.