Progranulin/PGRN 蛋白, Human (HEK293, His)

EpCAM/TROP1 protein is a cell surface protein expressed in a variety of epithelial tissues. It plays a crucial role in cell adhesion, proliferation and differentiation. Progranulin/PGRN Protein, Human (HEK293, His) is the recombinant human-derived Progranulin/PGRN protein, expressed by HEK293 , with C-10*His labeled tag. The total length of Progranulin/PGRN Protein, Human (HEK293, His) is 576 a.a., with molecular weight of ~93.3 kDa.

颗粒体蛋白前体/PGRN 蛋白代表一种 88 kDa 的前体蛋白，也称为上皮蛋白原和 PC 细胞衍生的生长因子，从该蛋白中裂解出称为颗粒体蛋白的分泌型糖基化肽家族。这种裂解产生成熟的颗粒蛋白，进一步加工成活性 6 kDa 肽，包括颗粒蛋白 A、颗粒蛋白 B、颗粒蛋白 C 等。上皮蛋白 1 和 2 分别与颗粒蛋白 A 和 B 同义。颗粒蛋白家族具有 7.5 个高度保守的 12-半胱氨酸颗粒蛋白/上皮蛋白基序重复，在调节细胞生长中发挥着至关重要的作用，其各种成员充当抑制剂、刺激剂或对细胞生长具有双重作用。颗粒体蛋白前体/PGRN 广泛表达，在骨髓 (RPKM 141.7)、肺 (RPKM 139.8) 和 25 个其他组织中表现出升高的水平，强调了其在多个器官的不同生理过程中的潜在重要性。

Human

HEK293

C-10*His

NP_002078.1 (T18-L593)

2896  [NCBI]

Approximately 93.3 kDa

Greater than 95% as determined by reducing SDS-PAGE.

溶液.

Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.