PRTN3 蛋白, Human (S203A, HEK293, His)

PRTN3, a serine protease, broadly targets elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV in vitro, playing a crucial role in extracellular matrix degradation. It modulates endothelial cell barrier function by cleaving and activating the receptor F2RL1/PAR-2, enhancing vascular integrity during neutrophil transendothelial migration. Its potential involvement in this process, particularly when associated with CD177, underscores its significance in immune-related functions. PRTN3 Protein, Human (S203A, HEK293, His) is the recombinant human-derived PRTN3 protein, expressed by HEK293 , with C-His labeled tag and I28-P256 mutation. The total length of PRTN3 Protein, Human (S203A, HEK293, His) is 229 a.a., with molecular weight of ~26.57 kDa.

PRTN3 是一种丝氨酸蛋白酶，具有广泛的底物特异性，在体外靶向弹性蛋白、纤连蛋白、层粘连蛋白、玻连蛋白和 I、III 和 IV 型胶原蛋白。其酶活性在这些细胞外基质成分的降解中起着至关重要的作用。此外，PRTN3 通过裂解和激活受体 F2RL1/PAR-2 参与内皮细胞屏障功能的调节，从而增强中性粒细胞跨内皮迁移过程中的血管完整性。值得注意的是，它可能参与中性粒细胞跨内皮迁移，特别是与 CD177 相关时，强调了它在免疫相关过程中的重要性。

Human

HEK293

C-His

P24158 (S203A, I28-P256)

5657  [NCBI]

Approximately 26.57 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.