PTK7 蛋白, Human (HEK293, His)

The PTK7 protein is an inactive tyrosine kinase that plays a key role in both non-canonical and canonical Wnt signaling pathways. Effects include cell adhesion, migration, polarity, proliferation, actin cytoskeleton reorganization, and apoptosis. PTK7 Protein, Human (HEK293, His-Avi) is the recombinant human-derived PTK7 protein, expressed by HEK293 , with C-Avi, C-His labeled tag.

PTK7 蛋白是一种无活性的酪氨酸激酶，在 Wnt 信号传导通路中发挥着重要作用，是非经典（Wnt/平面细胞极性信号传导）和经典 Wnt 信号传导通路的组成部分。它涉及多种细胞过程，包括细胞粘附、迁移、极性、增殖、肌动蛋白细胞骨架重组和凋亡。PTK7 还有助于关键的发育事件，例如胚胎发生、上皮组织组织和血管生成。值得注意的是，它与 CTNNB1 相互作用，强调了它参与 Wnt 通路调节及其对细胞功能的影响，在正常和病理情况下具有更广泛的影响。

Human

HEK293

C-Avi;C-His

Q13308-1 (A31-T704)

5754  [NCBI]

80-115 kDa

Greater than 95% as determined by Tris-Bis PAGE.

无菌粉末.

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Normally 5% trehalose is added as protectant before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.