1. Gene
  2. PTK7 - protein tyrosine kinase 7 (inactive) Gene

PTK7 - protein tyrosine kinase 7 (inactive) Gene

中文名称:蛋白酪氨酸激酶 7 (无活性)

种属: Homo sapiens

同用名: CCK4; CCK-4

基因 ID: 5754 | 基因类型: protein coding

关于 PTK7

Cytogenetic location: 6p21.1 Genomic coordinates (GRCh38): 6:43,076,314-43,161,715 (from NCBI)

This gene has 20 transcripts (splice variants) and 229 orthologues. Broad expression in endometrium (RPKM 43.5), ovary (RPKM 31.2) and 19 other tissues.

功能概要

该基因编码受体蛋白酪氨酸激酶蛋白家族的成员,该蛋白可跨细胞膜转导细胞外信号。编码的蛋白质缺乏可检测的催化酪氨酸激酶活性,参与 Wnt 信号通路,并在包括极性和粘附在内的多种细胞过程中发挥作用。已经观察到该基因编码多种亚型的可变剪接转录物变体。[RefSeq 提供,2012 年 7 月]

This gene encodes a member of the receptor protein tyrosine kinase family of proteins that transduce extracellular signals across the cell membrane. The encoded protein lacks detectable catalytic tyrosine kinase activity, is involved in the Wnt signaling pathway and plays a role in multiple cellular processes including polarity and adhesion. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

PTK7 基因产物(5)

mRNA Protein Name
NM_001270398.2 NP_001257327.1 inactive tyrosine-protein kinase 7 isoform e
NM_002821.5 NP_002812.2 inactive tyrosine-protein kinase 7 isoform a precursor
NM_152880.4 NP_690619.1 inactive tyrosine-protein kinase 7 isoform b precursor
NM_152881.4 NP_690620.1 inactive tyrosine-protein kinase 7 isoform c precursor
NM_152882.4 NP_690621.1 inactive tyrosine-protein kinase 7 isoform d precursor

PTK7 蛋白结构

I-set

I-set: Immunoglobulin I-set domain (33 - 114)

Ig_2

Ig_2: Immunoglobulin domain (137 - 217)

I-set

I-set: Immunoglobulin I-set domain (229 - 302)

I-set

I-set: Immunoglobulin I-set domain (347 - 408)

I-set

I-set: Immunoglobulin I-set domain (415 - 498)

I-set

I-set: Immunoglobulin I-set domain (503 - 588)

I-set

I-set: Immunoglobulin I-set domain (593 - 679)

Pkinase_Tyr

Pkinase_Tyr: Protein tyrosine kinase (799 - 1061)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1070 a.a.
蛋白主名 其他名称

inactive tyrosine-protein kinase 7

PTK7 protein tyrosine kinase 7

重组 PTK7 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71821 PTK7 Protein, Human (P.pastoris, His) Q13308-1 (A31-T704) ≥95%
HY-P78398 PTK7 Protein, Human (HEK293, His) Q13308-1 (A31-T704) ≥95%

关联疾病

疾病名称 别名
Panic Disorder

Panic Anxiety Syndrome

Panic

Panic Disorder 1

Episodic Paroxysmal Anxiety Disorder

Anxiety

Anxiety Disorder

Anxiety Disorders

Anxiety State

Anxieties

Anxiety Neurosis

Agoraphobia

Fear Of Open Spaces

Phobia Of Going Out

Neural Tube Defects

Spina Bifida

Neural Tube Defect

NTD

Neural Tube Defects, Susceptibility To

Spinal Dysraphism

Spina Bifida, Susceptibility To

Rachischisis

Cleft Spine

Open Spine

Hydrocele Spinalis

Neural Tube Defect Nos

Sb - [Spina Bifida]

Spinal Hernia Nos

Spinal Fissure Nos

Scoliosis
Myelomeningocele

Meningomyelocele

Phobic Disorder

Phobic Disorders

Phobic Anxiety Disorder

Syringomyelia

Hydromyelia

Strabismus

Strabismus, Susceptibility To

Strabismus, Susceptibility To, 1

Strabismus 1

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Bos taurus PTK7 VGNC VGNC:54670
Felis catus PTK7 VGNC VGNC:102498
Macaca mulatta PTK7 VGNC VGNC:83451
Mus musculus PTK7 MGD MGI:1918711
Rattus norvegicus PTK7 RGD RGD:1310472
Macaca fascicularis PTK7 NCBI NCBI:102126644
Leporidae PTK7 NCBI
Others PTK7 NCBI