2. Gene
  3. PTK7 - protein tyrosine kinase 7 (inactive) Gene

PTK7 - protein tyrosine kinase 7 (inactive) Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：蛋白酪氨酸激酶 7 (无活性)

种属: Homo sapiens

同用名: CCK4; CCK-4

基因 ID: 5754 | 基因类型: protein coding

关于 PTK7

Cytogenetic location: 6p21.1 Genomic coordinates (GRCh38): 6:43,076,314-43,161,715 (from NCBI)

This gene has 20 transcripts (splice variants) and 229 orthologues. Broad expression in endometrium (RPKM 43.5), ovary (RPKM 31.2) and 19 other tissues.

功能概要

该基因编码受体蛋白酪氨酸激酶蛋白家族的成员，该蛋白可跨细胞膜转导细胞外信号。编码的蛋白质缺乏可检测的催化酪氨酸激酶活性，参与 Wnt 信号通路，并在包括极性和粘附在内的多种细胞过程中发挥作用。已经观察到该基因编码多种亚型的可变剪接转录物变体。[RefSeq 提供，2012 年 7 月]

This gene encodes a member of the receptor protein tyrosine kinase family of proteins that transduce extracellular signals across the cell membrane. The encoded protein lacks detectable catalytic tyrosine kinase activity, is involved in the Wnt signaling pathway and plays a role in multiple cellular processes including polarity and adhesion. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

PTK7 基因产物(5)

mRNA Protein Name
NM_001270398.2 NP_001257327.1 inactive tyrosine-protein kinase 7 isoform e
NM_002821.5 NP_002812.2 inactive tyrosine-protein kinase 7 isoform a precursor
NM_152880.4 NP_690619.1 inactive tyrosine-protein kinase 7 isoform b precursor
NM_152881.4 NP_690620.1 inactive tyrosine-protein kinase 7 isoform c precursor
NM_152882.4 NP_690621.1 inactive tyrosine-protein kinase 7 isoform d precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
21132015 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in actin cytoskeleton organization IMP
IMP: 通过突变表型推断
20837484 GOA
involved in cell migration IMP
IMP: 通过突变表型推断
20837484 GOA
involved in cellular response to retinoic acid IMP
IMP: 通过突变表型推断
17910947 GOA
involved in positive regulation of canonical Wnt signaling pathway IMP
IMP: 通过突变表型推断
21132015 GOA
involved in positive regulation of neuron projection development IMP
IMP: 通过突变表型推断
17910947 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell-cell junction IDA
IDA: 通过直接分析推断
20837484 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PTK7 蛋白结构

I-set

I-set: Immunoglobulin I-set domain (33 - 114)

Ig_2

Ig_2: Immunoglobulin domain (137 - 217)

I-set

I-set: Immunoglobulin I-set domain (229 - 302)

I-set

I-set: Immunoglobulin I-set domain (347 - 408)

I-set

I-set: Immunoglobulin I-set domain (415 - 498)

I-set

I-set: Immunoglobulin I-set domain (503 - 588)

I-set

I-set: Immunoglobulin I-set domain (593 - 679)

Pkinase_Tyr

Pkinase_Tyr: Protein tyrosine kinase (799 - 1061)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1070 a.a.
蛋白主名 其他名称

inactive tyrosine-protein kinase 7

PTK7 protein tyrosine kinase 7

PTK7 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
PTK7 Q13308 KRTAP10-8 Homo sapiens P60410
Y2H Prey Pooling
32296183
种属内
PTK7 Q13308 KRTAP10-8 Homo sapiens P60410
Y2H Array
32296183
种属内
PTK7 Q13308 MTUS2 Homo sapiens Q5JR59-3
Y2H Array
32296183
种属内
PTK7 Q13308 MTUS2 Homo sapiens Q5JR59-3
Y2H Prey Pooling
32296183
种属内
PTK7 Q13308 MTUS2 Homo sapiens Q5JR59-3
Validated Y2H
32296183
种属内
PTK7 Q13308 KRTAP1-3 Homo sapiens Q8IUG1
Y2H Prey Pooling
32296183
种属内
PTK7 Q13308 KRTAP1-3 Homo sapiens Q8IUG1
Y2H Array
32296183
种属内
PTK7 Q13308 NOTCH2NLC Homo sapiens P0DPK4
Y2H Prey Pooling
32296183
种属内
PTK7 Q13308 NOTCH2NLC Homo sapiens P0DPK4
Y2H Array
32296183
种属内
PTK7 Q13308 CTNNB1 Homo sapiens P35222
Anti Bait CoIP
21132015
种属内
PTK7 Q13308 MDFI Homo sapiens Q99750
Y2H Prey Pooling
32296183
种属内
PTK7 Q13308 MDFI Homo sapiens Q99750
Validated Y2H
32296183
种属内
PTK7 Q13308 MDFI Homo sapiens Q99750
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 PTK7 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71821 PTK7 Protein, Human (P.pastoris, His) Q13308-1 (A31-T704) ≥95%
HY-P78398 PTK7 Protein, Human (HEK293, His) Q13308-1 (A31-T704) ≥95%

关联疾病

疾病名称 别名
Panic Disorder

Panic Anxiety Syndrome

Panic

Panic Disorder 1

Episodic Paroxysmal Anxiety Disorder
Anxiety

Anxiety Disorder

Anxiety Disorders

Anxiety State

Anxieties

Anxiety Neurosis
Agoraphobia

Fear Of Open Spaces

Phobia Of Going Out
Neural Tube Defects

Spina Bifida

Neural Tube Defect

NTD

Neural Tube Defects, Susceptibility To

Spinal Dysraphism

Spina Bifida, Susceptibility To

Rachischisis

Cleft Spine

Open Spine

Hydrocele Spinalis

Neural Tube Defect Nos

Sb - [Spina Bifida]

Spinal Hernia Nos

Spinal Fissure Nos
Scoliosis
Myelomeningocele

Meningomyelocele
Phobic Disorder

Phobic Disorders

Phobic Anxiety Disorder
Syringomyelia

Hydromyelia
Strabismus

Strabismus, Susceptibility To

Strabismus, Susceptibility To, 1

Strabismus 1
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Clinical Phase
抗体抑制剂 (2)
目录号 产品名 作用方式
纯度 Phase
HY-P99828 Cofetuzumab Inhibitor 96.53% Phase 1
HY-P99829 Cofetuzumab pelidotin Inhibitor 99.67% Phase 1
Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-160493 PTK7/β-catenin-IN-6 Inhibitor / 否
HY-160488 PTK7/β-catenin-IN-1 Inhibitor 99.99% 否
HY-160489 PTK7/β-catenin-IN-2 Inhibitor 96.96% 否
HY-RS11404 PTK7 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus PTK7 VGNC VGNC:54670
Felis catus PTK7 VGNC VGNC:102498
Macaca mulatta PTK7 VGNC VGNC:83451
Mus musculus PTK7 MGD MGI:1918711
Rattus norvegicus PTK7 RGD RGD:1310472
Macaca fascicularis PTK7 NCBI NCBI:102126644
Leporidae PTK7 NCBI
Others PTK7 NCBI
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