PTK7 蛋白, Rabbit (HEK293, His)

The PTK7 protein is an inactive tyrosine kinase that plays a key role in both non-canonical and canonical Wnt signaling pathways. Effects include cell adhesion, migration, polarity, proliferation, actin cytoskeleton reorganization, and apoptosis. PTK7 Protein, Rabbit (HEK293, His) is the recombinant Rabbit-derived PTK7 protein, expressed by HEK293 , with C-10*His labeled tag. The total length of PTK7 Protein, Rabbit (HEK293, His) is 582 a.a., with molecular weight of approximately 110 kDa.

PTK7 蛋白是一种无活性的酪氨酸激酶，在 Wnt 信号传导通路中发挥着重要作用，是非经典（Wnt/平面细胞极性信号传导）和经典 Wnt 信号传导通路的组成部分。它涉及多种细胞过程，包括细胞粘附、迁移、极性、增殖、肌动蛋白细胞骨架重组和凋亡。PTK7 还有助于关键的发育事件，例如胚胎发生、上皮组织组织和血管生成。值得注意的是，它与 CTNNB1 相互作用，强调了它参与 Wnt 通路调节及其对细胞功能的影响，在正常和病理情况下具有更广泛的影响。

Immobilized PTK-7 at 2 μg/mL (100 μL/well) can bind Biotinylated Wnt3a protein. The ED₅₀ for this effect is 8.625 μg/mL.

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  Immobilized PTK-7 at 2 μg/mL (100 μL/well) can bind Biotinylated Wnt3a protein. The ED₅₀ for this effect is 8.625 μg/mL.

Rabbit

HEK293

C-10*His

G1SIJ6-1 (A31-T612)

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AIVFIKEPSSQDALQGRRALLRCEVEAPAPVHVYWLLNGAPVQDTERRFVQDTERRFPQVSSLSFTAVDRLQDSGAFQCVARDNVTGEEARSANASFNIKWIEGGPVVLKQPASEAEIQPQTQVTLRCHVDGHPRPTYQWFRDGTPLSDGQSNHTVSSKERNLTLRPATPEHSGVYSCCAHNAFGQACSSQNFTLNIAEIEDMPPFEPRVFTAGSEERVACLPPHGLPEPSVWWEQAGVRLPTHGRVYQKGHELVFADTAESDAGVYTCHAANLAGQRRQDVNITVATVPTWLEKPQDSQLEEGRPGYLHCLTQATPKPTVVWYRNQMLISEDSRFEVSKNGTLRINSVEVYDGTWYRCVSSTPAGSIEAQARVQVLEKLKFTPPPQPQQCMEFDKEATVPCSATGREKPTIKWIRADGSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVAVFITFKVEPERTTVYQGHTALLRCEAQGDPKPLIQWKGKDRILDPSKLGPRMHIFQNGSLVIHDVAPEDSGRYTCIAGNSCNIKHTEAPLYVVDKPTPEESEGPGSPPPYKMIQT

approximately 110 kDa

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  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized a 0.22 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.