PVRIG 蛋白, Cynomolgus (HEK293, His)

The PVRIG protein functions as a cell surface receptor for NECTIN2 and may serve as a co-inhibitory receptor capable of inhibiting T-cell receptor-mediated signaling. Upon interaction with NECTIN2, PVRIG inhibits T cell proliferation, suggesting its potential role in regulating immune responses. PVRIG Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived PVRIG protein, expressed by HEK293 , with C-6*His labeled tag. The total length of PVRIG Protein, Cynomolgus (HEK293, His) is 131 a.a., with molecular weight of 20-30 kDa.

PVRIG（含 PVR 相关免疫球蛋白结构域）蛋白被确定为 NECTIN2 的细胞表面受体，作为潜在的共抑制受体，抑制 T 细胞受体介导的信号。与 NECTIN2 相互作用后，PVRIG 通过抑制 T 细胞增殖发挥其抑制作用。值得注意的是，PVRIG 与 NECTIN2 的 CD226 进行竞争性结合，这意味着它在与激活受体竞争的免疫反应中发挥调节作用。这种与 CD226 的竞争性相互作用强调了 PVRIG 参与调节 T 细胞激活过程中激活信号和抑制信号之间的微妙平衡。

Cynomolgus

HEK293

C-6*His

A0A2K5WVV8 (T41-D171)

102127364  [NCBI]

TPEVWVQVQMEATELSSFTVHCGFLGPGSISLVTVSWGGPDGAGGTKLAVLHPELGTRQWAPARQARWETQSSISLALEDSGASSPFANTTFCCKFASFPEGSWESCGSLPPSSDPGLSAPPTPVPILRAD

20-30 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US;may vary elsewhere.