RCN3 蛋白, Rat (HEK293, His)

The RCN3 protein is a possible molecular chaperone critical for protein biosynthesis and transport within the endoplasmic reticulum. Its involvement extends to the biosynthesis and transport of key proteins, including SP-A, SP-D, and ABCA3, highlighting the importance of pulmonary surfactant homeostasis. RCN3 Protein, Rat (HEK293, His) is the recombinant rat-derived RCN3 protein, expressed by HEK293 , with C-His labeled tag. The total length of RCN3 Protein, Rat (HEK293, His) is 304 a.a., with molecular weight of ~36.4 KDa.

RCN3 蛋白被认为是一种可能的分子伴侣，在内质网内协助蛋白质生物合成和运输方面发挥着至关重要的作用。它的参与延伸到关键蛋白质的正确生物合成和运输，包括肺表面活性剂相关蛋白 A/SP-A、肺表面活性剂相关蛋白 D/SP-D 和脂质转运蛋白 ABCA3，突出了其在肺表面活性剂稳态中的重要性。此外，RCN3 通过负调节 I 型和 III 型胶原蛋白的分泌而表现出抗纤维化活性。值得注意的是，这种钙结合蛋白短暂地与未成熟的 PCSK6 结合，调节其分泌并表明其在 PCSK6 的成熟和分泌过程中发挥作用。RCN3 的多方面功能强调了其在维持细胞稳态中的重要性，特别是在蛋白质生物合成、分泌和抗纤维化过程中。

Rat

HEK293

C-His

I6L9G5 (K21-H324)

494125  [NCBI]

KPSPDAGPHGQDRVHHGTPLSEAPHDDAHGNFQYDHEAFLGRDVAKEFDQLTPEESQARLGRIVDRMDLAGDSDGWVSLAELRAWIAHTQQRHIRDSVSAAWHTYDTDRDGRVGWEELRNATYGHYEPGEEFHDVEDAETYKKMLARDERRFRVADQDGDSMATREELTAFLHPEEFPHMRDIVVAETLEDLDKNKDGYVQVEEYIADLYSAEPGEEEPAWVQTERQQFRDFRDLNKDGRLDGSEVGYWVLPPSQDQPLVEANHLLHESDTDKDGRLSKAEILSNWNMFVGSQATNYGEDLTRH

Approximately 40-50 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.