ROR1 蛋白, Human (sf9, His)

ROR1 protein's minimal kinase activity in vitro suggests an improbable role as a tyrosine kinase in vivo. It serves as a receptor for WNT5A, activating NFkB signaling and potentially inhibiting WNT3A signaling. Notably, ROR1 plays a vital role in the inner ear, facilitating innervation of auditory hair cells by spiral ganglion neurons. ROR1 Protein, Human (sf9, His) is the recombinant human-derived ROR1 protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of ROR1 Protein, Human (sf9, His) is 331 a.a., with molecular weight of 55-70 kDa.

ROR1 蛋白在体外表现出非常低的激酶活性，表明在体内不太可能发挥酪氨酸激酶的作用。它作为配体 WNT5A 的受体发挥作用，激活下游 NFkB 信号通路并可能抑制 WNT3A 介导的信号传导。值得注意的是，在内耳中，ROR1 对于促进螺旋神经节神经元对听毛细胞的神经支配至关重要。

1.The enzyme activity of this recombinant protein is testing in progress, we cannot offer a guarantee yet.
2.Anti-ROR1 Antibody, hFc Tag captured on CM5 Chip via Protein A can bind Human ROR1, His Tag with an affinity constant of 26.40 nM as determined in SPR assay (Biacore T200).

Human

Sf9 insect cells

C-His

Q01973 (M453-N783)

4919  [NCBI]

55-70 kDa

Greater than 95% as determined by reducing SDS-PAGE

溶液.

Supplied as sterile 20 mM Tris, 500 mM NaCl, 2 mM GSH, 3 mM DTT, 10% glycerol, pH 7.4

<1 EU/μg, determined by LAL method.

Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.