ROR1 - receptor tyrosine kinase like orphan receptor 1 Gene

中文名称：受体酪氨酸激酶样孤儿受体 1

种属: Homo sapiens

同用名: NTRKR1; dJ537F10.1

基因 ID: 4919 | 基因类型: protein coding

关于 ROR1

Cytogenetic location: 1p31.3 Genomic coordinates (GRCh38): 1:63,774,017-64,181,498 (from NCBI)

This gene has 3 transcripts (splice variants), 209 orthologues, 53 paralogues and is associated with 2 phenotypes. Ubiquitous expression in lung (RPKM 2.7), endometrium (RPKM 2.2) and 23 other tissues.

功能概要

该基因编码一种受体酪氨酸激酶样孤儿受体，可调节中枢神经系统的神经突生长。编码的蛋白质是一种糖基化的 I 型膜蛋白，属于细胞表面受体的 ROR 亚家族。它是一种假激酶，缺乏催化活性，可能与非经典 Wnt 信号通路相互作用。该基因在早期胚胎发育过程中高度表达，但在成年组织中表达水平非常低。该基因表达增加与 B 细胞慢性淋巴细胞白血病有关。可变剪接导致编码不同异构体的多个转录变体。[RefSeq 提供，2012 年 6 月]

This gene encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors. It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway. This gene is highly expressed during early embryonic development but expressed at very low levels in adult tissues. Increased expression of this gene is associated with B-cell chronic lymphocytic leukaemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2012]

ROR1 基因产物(2)

mRNA	Protein	Name
NM_001083592.2	NP_001077061.1	inactive tyrosine-protein kinase transmembrane receptor ROR1 isoform 2 precursor
NM_005012.4	NP_005003.2	inactive tyrosine-protein kinase transmembrane receptor ROR1 isoform 1 precursor

ROR1 蛋白结构

I-set

Kringle

Pkinase_Tyr

0
200
400
600
800
937 a.a.

蛋白主名

其他名称

inactive tyrosine-protein kinase transmembrane receptor ROR1

neurotrophic tyrosine kinase, receptor-related 1

重组 ROR1 蛋白

目录号	产品名	蛋白编号	纯度
HY-P70732	ROR1 Protein, Human (HEK293, His)	Q01973-1 (Q30-E403)	≥95%
HY-P72410	ROR1 Protein, Human (Biotinylated, HEK293, His-Avi)	Q01973-1 (Q30-E403)	≥95%
HY-P73390	ROR1 Protein, Human (sf9, His)	Q01973 (M453-N783)	≥95%
HY-P78510	ROR1 Protein, Human (HEK293, His-Avi)	Q01973-1 (Q30-E403)	≥95%

关联疾病

疾病名称

别名

Deafness, Autosomal Recessive 108

DFNB108

Deafness, Autosomal Recessive, 108

Autosomal Recessive Non-Syndromic Sensorineural Deafness Type Dfnb

Autosomal Recessive Isolated Neurosensory Deafness Type Dfnb	Autosomal Recessive Isolated Neurosensory Hearing Loss Type Dfnb
Autosomal Recessive Isolated Sensorineural Deafness Type Dfnb	Autosomal Recessive Isolated Sensorineural Hearing Loss Type Dfnb
Autosomal Recessive Non-Syndromic Neurosensory Deafness Type Dfnb	Autosomal Recessive Non-Syndromic Neurosensory Hearing Loss Type Dfnb
Autosomal Recessive Non-Syndromic Sensorineural Hearing Loss Type Dfnb

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

Robinow Syndrome

Acral Dysostosis With Facial And Genital Abnormalities	Fetal Face Syndrome
Robinow Dwarfism	Mesomelic Dwarfism-Small Genitalia Syndrome
Robinow-Silverman-Smith Syndrome	Costovertebral Segmentation Defect With Mesomelia
Covesdem Syndrome	Robinow'S Syndrome
Robinow-Silverman Syndrome

Sensorineural Hearing Loss

Sensory Hearing Loss	Sensorineural Deafness
Sensorineural Hearing Loss Disorder	Hearing Loss, Sensorineural
Central Hearing Loss	High Frequency Deafness
High Frequency Hearing Loss	High-Frequency Hearing Loss
Perceptive Deafness	Perceptive Hearing Loss
Perceptive Hearing Loss Or Deafness	Hearing Loss Sensorineural
Deafness Sensorineural	Hearing Loss High-Frequency
Hearing Loss, Central	Hearing Loss, High-Frequency

Leukemia, Chronic Lymphocytic

Chronic Lymphocytic Leukemia	B-Cell Chronic Lymphocytic Leukemia
CLL	B-Cell Chronic Lymphoid Leukemia
Chronic Lymphatic Leukemia	Chronic Lymphocytic Leukaemia
Lymphoplasmacytic Leukemia	Small Lymphocytic Lymphoma
Leukemia, Chronic Lymphatic	B-Cell Chronic Lymphocytic Leukaemia
Chronic Lymphatic Leukaemia	Lymphoplasmacytic Leukaemia
B Cell Chronic Lymphocytic Leukemia	Chronic B-Cell Lymphocytic Leukemia
Leukemia, Lymphocytic, Chronic	B-Cll
Chronic Lymphoid Leukemia	Leukemia Lymphocytic Chronic
Lymphoma Small Lymphocytic	Leukemia, Lymphocytic, Chronic, B-Cell

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

目录号	产品名	作用方式	纯度	Phase
HY-P99201	Zilovertamab	Inhibitor	98.21%	Phase 3
HY-P99956	Zilovertamab vedotin	Inducer	98.15%	Phase 3

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-139534	ARI-1		99.76%	否
HY-139534A	(S)-ARI-1		99.80%	否
HY-117947	(R)-OR-S1		/	否
HY-161096	Antitumor agent-127		/	否
HY-162640	ROR1-IN-1	Inhibitor	/	否
HY-RS12124	ROR1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-160790	β-Glu-PNP		/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	ROR1	RGD	RGD:1559469
Bos taurus	ROR1	VGNC	VGNC:55673
Canis familiaris	ROR1	VGNC	VGNC:45693
Mus musculus	ROR1	MGD	MGI:1347520
Macaca mulatta	ROR1	VGNC	VGNC:76715
Felis catus	ROR1	VGNC	VGNC:64719
Others	ROR1	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

ROR1 - receptor tyrosine kinase like orphan receptor 1 Gene

关于 ROR1

功能概要

ROR1 基因产物(2)

ROR1 蛋白结构

重组 ROR1 蛋白

关联疾病

直系同源

热门区域

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ROR1 - receptor tyrosine kinase like orphan receptor 1 Gene

关于 ROR1

功能概要

ROR1 基因产物(2)

ROR1 蛋白结构

重组 ROR1 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z