1. 重组蛋白
  2. CAR-T related Proteins Receptor Proteins Enzymes & Regulators Biotinylated Proteins
  3. ROR1 Receptor Tyrosine Kinases Protein Tyrosine Kinases
  4. ROR family
  5. ROR1 蛋白, Human (HEK293, His-Avi)

ROR1 蛋白, Human (HEK293, His-Avi)

目录号: HY-P78510
产品使用指南

ROR1 蛋白在体外的最小激酶活性表明其在体内不太可能发挥酪氨酸激酶的作用。它作为 WNT5A 的受体,激活 NFkB 信号传导并可能抑制 WNT3A 信号传导。值得注意的是,ROR1 在内耳中起着至关重要的作用,促进螺旋神经节神经元对听毛细胞的神经支配。ROR1 蛋白, Human (HEK293, His-Avi) 是重组的 ROR1 蛋白,由 HEK293 表达,带有 C-Avi, C-His 标签。

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描述

ROR1 protein's minimal kinase activity in vitro suggests an improbable role as a tyrosine kinase in vivo. It serves as a receptor for WNT5A, activating NFkB signaling and potentially inhibiting WNT3A signaling. Notably, ROR1 plays a vital role in the inner ear, facilitating innervation of auditory hair cells by spiral ganglion neurons. ROR1 Protein, Human (HEK293, His-Avi) is the recombinant human-derived ROR1 protein, expressed by HEK293 , with C-Avi, C-His labeled tag.

研究背景

ROR1 蛋白在体外表现出非常低的激酶活性,表明在体内不太可能发挥酪氨酸激酶的作用。它作为配体 WNT5A 的受体发挥作用,激活下游 NFkB 信号通路并可能抑制 WNT3A 介导的信号传导。值得注意的是,在内耳中,ROR1 对于促进螺旋神经节神经元对听毛细胞的神经支配至关重要。

种属

Human

表达系统

HEK293

标签

C-Avi;C-His

蛋白编号

Q01973-1 (Q30-E403)

基因 ID
蛋白结构
N-term
ROR1 (Q30-E403)
Accession # Q01973-1
His-Avi
C-term
同用名
ROR1; NTRKR1; dJ537F10.1
分子量

55-70 kDa

纯度

Greater than 95% as determined by Tris-Bis PAGE.

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
ROR1 Protein, Human (HEK293, His-Avi)
目录号:
HY-P78510
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