S100A1 蛋白, Human

S100A1 is a small calcium-binding protein that plays critical roles in multiple processes, including Ca(2+) homeostasis and cardiomyocyte regulation. Elevated intracellular Ca(2+) triggers conformational changes in S100A1, thereby interacting with key proteins in cardiomyocytes such as RYR1, RYR2, ATP2A2 and F1-ATPase. S100A1 Protein, Human is the recombinant human-derived S100A1 protein, expressed by E. coli , with tag free. The total length of S100A1 Protein, Human is 94 a.a., with molecular weight of ~10.5 kDa.

S100A1 是一种小型钙结合蛋白，在各种生物过程中发挥着至关重要的作用，包括 Ca(2+) 稳态、软骨细胞生物学和心肌细胞调节。当细胞内 Ca(2+) 水平增加时，S100A1 与钙结合，引发构象变化，促进与特定靶蛋白的相互作用，随后调节其活性。特别是，在心肌细胞中，S100A1 通过与兰尼碱受体 RYR1 和 RYR2、肌浆网 Ca(2+)-ATPase/ATP2A2 和线粒体 F1- 等关键蛋白相互作用，协调控制肌浆网 Ca(2+) 循环和线粒体功能的网络。ATP酶。这种多面蛋白质还有助于舒张期 Ca(2+) 解离和肌丝力学，增强舒张期的松弛。S100A1 以两条 α 链、两条 β 链或各一条的二聚体形式存在，并与 S100P 形成异二聚体。此外，它还与 AGER、CAPZA1、FKBP4、RYR1、RYR2、CACYBP、PPP5C、ATP2A2、PLN、ATP5F1A 和 ATP5F1B 等蛋白质进行各种相互作用，以钙依赖性方式参与多种细胞过程。

Measured by its binding ability in a functional ELISA.

Human

E. coli

Tag Free

P23297 (M1-S94)

6271  [NCBI]

Approximately 10.5 kDa

Greater than 95% as determined by reducing SDS-PAGE.

溶液

Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.