S100A1 蛋白, Mouse (His)

S100A1 is a small calcium-binding protein that plays an important regulatory role in Ca(2+) homeostasis, chondrocyte biology, and cardiomyocyte function.In response to elevated intracellular Ca(2+) levels, S100A1 undergoes conformational changes and interacts with key proteins in cardiomyocytes, such as RYR1, RYR2, ATP2A2, and F1-ATPase.S100A1 Protein, Mouse (His) is the recombinant mouse-derived S100A1 protein, expressed by E.coli , with N-His labeled tag.

S100A1 是一种小型钙结合蛋白，在多种生物过程中发挥着关键作用，包括 Ca(2+) 稳态的调节、软骨细胞生物学和心肌细胞功能。为了响应细胞内 Ca(2+) 水平升高，S100A1 发生构象变化，从而能够与特定靶蛋白相互作用并调节其活性。在心肌细胞中，它通过与兰尼碱受体 RYR1 和 RYR2、肌浆网 Ca(2+)-ATPase/ATP2A2 和线粒体 F1-ATPase 等关键蛋白相互作用，协调控制肌浆网 Ca(2+) 循环和线粒体功能的网络。这种多面蛋白质有助于舒张期 Ca(2+) 解离和肌丝力学，增强舒张期的松弛。S100A1 形成两条 α 链、两条 β 链或各一条的二聚体，并且它还与 S100P 进行异二聚体相互作用。此外，它还与多种蛋白质相互作用，例如 AGER、CAPZA1、FKBP4、RYR1、RYR2、CACYBP、PPP5C、ATP2A2、PLN、ATP5F1A 和 ATP5F1B，以钙依赖性方式参与多种细胞过程。

Mouse

E. coli

N-His

P56565 (G2-S94)

20193  [NCBI]

Approximately 14 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.