S100A2 蛋白, Human

The S100A2 protein is a potential calcium sensor that actively promotes cellular calcium signaling and affects various physiological processes. As a homodimer, it interacts with TPR-containing proteins, including FKBP4, and participates in multiple molecular associations. S100A2 Protein, Human is the recombinant human-derived S100A2 protein, expressed by E. coli , with tag free. The total length of S100A2 Protein, Human is 98 a.a., with molecular weight of ~10.53 kDa.

S100A2 蛋白作为一种潜在的钙传感器和调节剂出现，积极促进细胞钙信号传导。通过与各种蛋白质（包括含 TPR 的蛋白质）相互作用，S100A2 间接影响许多生理过程。此外，它可能在抑制肿瘤细胞生长方面发挥作用。S100A2 作为同二聚体存在，与 FKBP4 相互作用，揭示了它参与多种分子关联。值得注意的是，它与 PPP5C 的钙依赖性相互作用（由 TPR 重复序列介导）调节 PPP5C 活性，强调了 S100A2 对细胞过程的调节影响。此外，最近的研究证明，它与 TPPP 的相互作用会抑制 TPPP 二聚化。S100A2 的多方面功能凸显了其在细胞信号传导和肿瘤生长抑制中发挥关键作用的潜力。

Measured  by its ability to chemoattract A549 Human non-small cell lung cancer cells.  The ED₅₀ this effect is 13.09 ng/mL, corresponding to a specific  activity is 7.64×10⁴ U/mg.

Human

E. coli

Tag Free

P29034 (M1-P98)

6273  [NCBI]

MMCSSLEQALAVLVTTFHKYSCQEGDKFKLSKGEMKELLHKELPSFVGEKVDEEGLKKLMGSLDENSDQQVDFQEYAVFLALITVMCNDFFQGCPDRP

Approximately 10.53 kDa

• 
  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.