S100A6 蛋白, Human (His)

The S100A6 protein is a key calcium sensor that actively promotes cellular calcium signaling and is involved in multiple processes, including actin cytoskeletal reorganization and cell motility. As a homodimer binding two calcium ions, it interacts with TPR-containing proteins, CACYBP, ANXA2, ANXA11, SUGT1, tropomyosin, TP53, PPP5C, and TPPP. S100A6 Protein, Human (His) is the recombinant human-derived S100A6 protein, expressed by E. coli , with N-6*His labeled tag. The total length of S100A6 Protein, Human (His) is 90 a.a., with molecular weight of ~12.0 kDa.

S100A6 蛋白作为关键的钙传感器和调节剂，积极促进细胞钙信号传导。通过与各种蛋白质（包括含 TPR 的蛋白质）相互作用，S100A6 间接参与多种生理过程，例如肌动蛋白细胞骨架的重组和细胞运动。S100A6 以由两个亚基头尾相连的同二聚体形式存在，以协作方式结合两个钙离子。它与 CACYBP、ANXA2、ANXA11、SUGT1 和原肌球蛋白的钙依赖性相互作用揭示了其在协调复杂分子相互作用中的作用。此外，S100A6 与 TP53 相互作用，对其 N 端结构域磷酸化的 TP53 显示出较高的亲和力，而对其 C 端结构域磷酸化的 TP53 显示出较低的亲和力。由 TPR 重复序列介导的与 PPP5C 的相互作用是钙依赖性的，并调节 PPP5C 活性，强调 S100A6 在细胞过程中的调节影响。此外，正如最近的研究报道，它与 TPPP 的相互作用会抑制 TPPP 二聚化。

Human

E. coli

N-6*His

P06703 (M1-G90)

6277  [NCBI]

MACPLDQAIGLLVAIFHKYSGREGDKHTLSKKELKELIQKELTIGSKLQDAEIARLMEDLDRNKDQEVNFQEYVTFLGALALIYNEALKG

Approximately 12.0 kDa

Greater than 95% as determined by reducing SDS-PAGE.

溶液.

Supplied as a 0.2 μm filtered solution of 20 mM Tris-HCl, 150 mM NaCl, 20% Glycerol, 1 mM EDTA, pH 8.0.

<1 EU/μg, determined by LAL method.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.