Syndecan-2 蛋白, Human (HEK293, His)

Syndecan-2 Protein is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. Syndecan-2 functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Syndecan-2 is necessary for tumor angiogenesis that facilitates tumor growth and metastasis. Syndecan-2 Protein, Human (HEK293, His) is the recombinant human-derived Syndecan-2 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Syndecan-2 Protein, Human (HEK293, His) is 126 a.a., with molecular weight of 25-40 kDa.

Syndecan-2 是一种跨膜（I 型）硫酸乙酰肝素蛋白聚糖，是 Syndecan 蛋白聚糖家族的成员。多配体聚糖介导细胞结合、细胞信号传导和细胞骨架组织，并且多配体聚糖受体是 HIV-1 tat 蛋白内化所必需的。Syndecan-2 作为完整的膜蛋白发挥作用，并通过其细胞外基质蛋白受体参与细胞增殖、细胞迁移和细胞-基质相互作用。Syndecan-2 表达的增加可能与细胞/底物相互作用和接触抑制的丧失直接相关，并有助于癌细胞的致瘤和转移潜力。Syndecan-2 对于促进肿瘤生长和转移的肿瘤血管生成是必需的。Syndecan-2 是造血干细胞 (HSC) 的一种新型标记物，可通过控制 Cdkn1c (p57) 的表达和 HSC 静止来调节 HSC 重新增殖能力。此外，Syndecan-2 还可抑制小鼠肺成纤维细胞中 TGF-β1 诱导的 α-SMA 表达、细胞收缩、增殖和迁移^[1][2][3]。

Human

HEK293

C-6*His

AAH49836.1 (E19-E144)

6383  [NCBI]

ESRAELTSDKDMYLDNSSIEEASGVYPIDDDDYASASGSGADEDVESPELTTTRPLPKILLTSAAPKVETTTLNIQNKIPAQTKSPEETDKEKVHLSDSERKMDPAEEDTNVYTEKHSDSLFKRTE

25-40 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of 20 mM Tris-Citrate, 150 mM NaCl, pH 7.0.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US;may vary elsewhere.