SDC2 - syndecan 2 Gene

中文名称：联癸烷 2

种属: Homo sapiens

同用名: HSPG; CD362; HSPG1; SYND2

基因 ID: 6383 | 基因类型: protein coding

关于 SDC2

Cytogenetic location: 8q22.1 Genomic coordinates (GRCh38): 8:96,493,813-96,611,790 (from NCBI)

This gene has 8 transcripts (splice variants), 228 orthologues and 3 paralogues. Broad expression in thyroid (RPKM 143.2), liver (RPKM 70.5) and 19 other tissues.

功能概要

该基因编码的蛋白质是跨膜 (I 型) 硫酸乙酰肝素蛋白多糖，是聚糖蛋白多糖家族的成员。聚合体介导细胞结合、细胞信号传导和细胞骨架组织，聚合体受体是 HIV-1 tat 蛋白内化所必需的。 syndecan-2 蛋白作为一种完整的膜蛋白发挥作用，并通过其细胞外基质蛋白受体参与细胞增殖、细胞迁移和细胞-基质相互作用。已在几种不同的肿瘤类型中检测到改变的 syndecan-2 表达。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-2 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-2 expression has been detected in several different tumor types. [provided by RefSeq, Jul 2008]

SDC2 基因产物(1)

mRNA	Protein	Name
NM_002998.4	NP_002989.2	syndecan-2 precursor

基因本体论

分子功能

分子功能 GO 注释	逻辑证据	参考文献	来源
enables PDZ domain binding	IPI IPI: 通过物理相互作用推断	18256285	GOA
enables identical protein binding	IPI IPI: 通过物理相互作用推断	18093920	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	9660868	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SDC2 蛋白结构

Syndecan

0
100
201 a.a.

蛋白主名

其他名称

syndecan-2

cell surface-associated heparan sulfate proteoglycan 1

重组 SDC2 蛋白

目录号	产品名	蛋白编号	纯度
HY-P70995	Syndecan-2 Protein, Human (HEK293, His)	AAH49836.1 (E19-E144)	≥95%

关联疾病

疾病名称

别名

Kaposi Sarcoma

Kaposi'S Sarcoma	Kaposi Sarcoma, Susceptibility To
Kaposi'S Sarcoma Of Lung	Kaposi'S Sarcoma Of Palate
Kaposi'S Sarcoma Of Soft Tissue	Kaposi'S Sarcoma-Associated Herpesvirus
Multiple Idiopathic Pigmented Hemangiosarcoma	Multiple Idiopathic Pigmented Hemangiosarcoma, Susceptibility To
African Lymphadenopathic Kaposi'S Sarcoma	Anal Kaposi'S Sarcoma
Cardiac Kaposi'S Sarcoma	Central Nervous System Kaposi'S Sarcoma
Conjunctival Kaposi'S Sarcoma	Corneal Kaposi'S Sarcoma
Cutaneous Kaposi'S Sarcoma	Esophageal Kaposi'S Sarcoma
Gallbladder Kaposi'S Sarcoma	Gastric Kaposi'S Sarcoma
Intestinal Kaposi'S Sarcoma	Kaposi'S Sarcoma Of Anus
Kaposi'S Sarcoma Of Central Nervous System	Kaposi'S Sarcoma Of Conjunctiva
Kaposi'S Sarcoma Of Cornea	Kaposi'S Sarcoma Of Esophagus
Kaposi'S Sarcoma Of Gastrointestinal Sites	Kaposi'S Sarcoma Of Heart
Kaposi'S Sarcoma Of Lymph Nodes	Kaposi'S Sarcoma Of Penis
Kaposi'S Sarcoma Of Skin	Kaposi'S Sarcoma Of Soft Tissues
Kaposi'S Sarcoma Of The Cns	Kaposi'S Sarcoma Of The Gallbladder
Kaposi'S Sarcoma Of The Prostate	Kaposi'S Sarcoma, Lung
Kaposi'S Sarcoma, Skin	Lymph Node Kaposi'S Sarcoma
Lymphadenopathic Kaposi'S Sarcoma	Palate Kaposi'S Sarcoma
Penis Kaposi'S Sarcoma	Prostate Kaposi'S Sarcoma
Pulmonary Kaposi'S Sarcoma	Soft Tissue Kaposi'S Sarcoma
Hhv8	Human Herpesvirus 8
Kshv	Kaposi Sarcoma Herpesvirus
Mediterranean Kaposi Sarcoma	Non Aids Related Kaposi Sarcoma
Sarcoma, Kaposi	Sarcoma, Kaposi, Susceptibility To
Non-Aids-Related Kaposi Sarcoma	Angiolymphoid Hyperplasia
Angiofollicular Ganglionic Hyperplasia	Multi-Centric Castleman'S Disease

Autism

Autistic Disorder	Autism Susceptibility 1
Childhood Autism	Autistic Disorder Of Childhood Onset
Infantile Autism	Kanner'S Syndrome
Autistic

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS12580	SDC2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	SDC2	VGNC	VGNC:54120
Mus musculus	SDC2	MGD	MGI:1349165
Macaca mulatta	SDC2	VGNC	VGNC:76998
Felis catus	SDC2	VGNC	VGNC:64944
Bos taurus	SDC2	VGNC	VGNC:34379
Rattus norvegicus	SDC2	RGD	RGD:3649
Others	SDC2	NCBI

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