2. Gene
  3. SDC2 - syndecan 2 Gene

SDC2 - syndecan 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：联癸烷 2

种属: Homo sapiens

同用名: HSPG; CD362; HSPG1; SYND2

基因 ID: 6383 | 基因类型: protein coding

关于 SDC2

Cytogenetic location: 8q22.1 Genomic coordinates (GRCh38): 8:96,493,813-96,611,790 (from NCBI)

This gene has 8 transcripts (splice variants), 228 orthologues and 3 paralogues. Broad expression in thyroid (RPKM 143.2), liver (RPKM 70.5) and 19 other tissues.

功能概要

该基因编码的蛋白质是跨膜 (I 型) 硫酸乙酰肝素蛋白多糖，是聚糖蛋白多糖家族的成员。聚合体介导细胞结合、细胞信号传导和细胞骨架组织，聚合体受体是 HIV-1 tat 蛋白内化所必需的。 syndecan-2 蛋白作为一种完整的膜蛋白发挥作用，并通过其细胞外基质蛋白受体参与细胞增殖、细胞迁移和细胞-基质相互作用。已在几种不同的肿瘤类型中检测到改变的 syndecan-2 表达。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-2 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-2 expression has been detected in several different tumor types. [provided by RefSeq, Jul 2008]

SDC2 基因产物(1)

mRNA Protein Name
NM_002998.4 NP_002989.2 syndecan-2 precursor
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables PDZ domain binding IPI
IPI: 通过物理相互作用推断
18256285 GOA
enables identical protein binding IPI
IPI: 通过物理相互作用推断
18093920 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
9660868 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SDC2 蛋白结构

Syndecan

Syndecan: Syndecan domain (136 - 199)

  • 0
  • 100
  • 201 a.a.
蛋白主名 其他名称

syndecan-2

cell surface-associated heparan sulfate proteoglycan 1

SDC2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
SDC2 P34741 ESRP1 Homo sapiens Q6NXG1
Y2H Array
32814053
种属内
SDC2 P34741 ESRP1 Homo sapiens Q6NXG1
Y2H Pooling
32814053
种属内
SDC2 P34741 ESRP1 Homo sapiens Q6NXG1
Validated Y2H
32814053
种属内
SDC2 P34741 KIF1B Homo sapiens O60333-2
Y2H Array
32814053
种属内
SDC2 P34741 KIF1B Homo sapiens O60333-2
Y2H Pooling
32814053
种属内
SDC2 P34741 KIF1B Homo sapiens O60333-2
Validated Y2H
32814053
种属内
SDC2 P34741 DMWD Homo sapiens G5E9A7
Validated Y2H
32814053
种属内
SDC2 P34741 DMWD Homo sapiens G5E9A7
Y2H Array
32814053
种属内
SDC2 P34741 DMWD Homo sapiens G5E9A7
Y2H Pooling
32814053
种属内
SDC2 P34741 NF1 Homo sapiens P21359
Y2H
11356864
种属内
SDC2 P34741 SDC1 Homo sapiens P18827
Anti Tag CoIP
33961781
种属内
SDC2 P34741 SDC1 Homo sapiens P18827
Comigration in Gel
18093920
种属内
SDC2 P34741 SDC2 Homo sapiens P34741
Comigration in Gel
18093920
种属内
SDC2 P34741 SDC4 Homo sapiens P31431
Anti Tag CoIP
33961781
种属内
SDC2 P34741 ccsb_13186 Homo sapiens EBI-25834291
Validated Y2H
32814053
种属内
SDC2 P34741 SDC2 Homo sapiens P34741
Y2H
21988832
种属内
SDC2 P34741 SDC4 Homo sapiens P31431
Comigration in Gel
18093920
种属内
SDC2 P34741 SDC2 Homo sapiens P34741
ToxCat
18093920
种属内
SDC2 P34741 ccsb_13186 Homo sapiens EBI-25834291
Y2H Array
32814053
种属内
SDC2 P34741 ASPH Homo sapiens Q12797-6
Validated Y2H
32296183
种属内
SDC2 P34741 ccsb_13186 Homo sapiens EBI-25834291
Y2H Pooling
32814053
种属内
SDC2 P34741 TOM1 Homo sapiens O60784-2
Validated Y2H
32814053
种属内
SDC2 P34741 TOM1 Homo sapiens O60784-2
Y2H Pooling
32814053
种属内
SDC2 P34741 TOM1 Homo sapiens O60784-2
Y2H Array
32814053
种属内
SDC2 P34741 NBL1 Homo sapiens P41271-2
Y2H Array
32814053
种属内
SDC2 P34741 NBL1 Homo sapiens P41271-2
Validated Y2H
32814053
种属内
SDC2 P34741 NBL1 Homo sapiens P41271-2
Y2H Pooling
32814053
种属内
SDC2 P34741 MAPK8IP2 Homo sapiens Q13387-4
Validated Y2H
32814053
种属内
SDC2 P34741 MAPK8IP2 Homo sapiens Q13387-4
Y2H Array
32814053
种属内
SDC2 P34741 MAPK8IP2 Homo sapiens Q13387-4
Y2H Pooling
32814053
种属内
SDC2 P34741 SDC3 Homo sapiens O75056
Comigration in Gel
18093920
种属内
SDC2 P34741 GRN Homo sapiens P28799-2
Y2H Array
32814053
种属内
SDC2 P34741 GRN Homo sapiens P28799-2
Validated Y2H
32814053
种属内
SDC2 P34741 GRN Homo sapiens P28799-2
Y2H Pooling
32814053
种属内
SDC2 P34741 RNF11 Homo sapiens Q9Y3C5
Validated Y2H
32814053
种属内
SDC2 P34741 RNF11 Homo sapiens Q9Y3C5
Y2H Array
32814053
种属内
SDC2 P34741 RNF11 Homo sapiens Q9Y3C5
Y2H Pooling
32814053
种属内
SDC2 P34741 SPRED1 Homo sapiens Q7Z699
Y2H Array
32814053
种属内
SDC2 P34741 SPRED1 Homo sapiens Q7Z699
Y2H Pooling
32814053
种属内
SDC2 P34741 SPRED1 Homo sapiens Q7Z699
Validated Y2H
32814053
种属内
SDC2 P34741 WFS1 Homo sapiens O76024
Y2H Pooling
32814053
种属内
SDC2 P34741 WFS1 Homo sapiens O76024
Validated Y2H
32814053
种属内
SDC2 P34741 WFS1 Homo sapiens O76024
Y2H Array
32814053
种属内
SDC2 P34741 GRN Homo sapiens P28799
Y2H Array
32814053
种属内
SDC2 P34741 GRN Homo sapiens P28799
Validated Y2H
32814053
种属内
SDC2 P34741 GRN Homo sapiens P28799
Y2H Pooling
32814053
种属内
SDC2 P34741 PIK3R1 Homo sapiens P27986-2
Validated Y2H
32814053
种属内
SDC2 P34741 PIK3R1 Homo sapiens P27986-2
Y2H Array
32814053
种属内
SDC2 P34741 PIK3R1 Homo sapiens P27986-2
Y2H Pooling
32814053
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 SDC2 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70995 Syndecan-2 Protein, Human (HEK293, His) AAH49836.1 (E19-E144) ≥95%

关联疾病

疾病名称 别名
Kaposi Sarcoma

Kaposi'S Sarcoma

Kaposi Sarcoma, Susceptibility To

Kaposi'S Sarcoma Of Lung

Kaposi'S Sarcoma Of Palate

Kaposi'S Sarcoma Of Soft Tissue

Kaposi'S Sarcoma-Associated Herpesvirus

Multiple Idiopathic Pigmented Hemangiosarcoma

Multiple Idiopathic Pigmented Hemangiosarcoma, Susceptibility To

African Lymphadenopathic Kaposi'S Sarcoma

Anal Kaposi'S Sarcoma

Cardiac Kaposi'S Sarcoma

Central Nervous System Kaposi'S Sarcoma

Conjunctival Kaposi'S Sarcoma

Corneal Kaposi'S Sarcoma

Cutaneous Kaposi'S Sarcoma

Esophageal Kaposi'S Sarcoma

Gallbladder Kaposi'S Sarcoma

Gastric Kaposi'S Sarcoma

Intestinal Kaposi'S Sarcoma

Kaposi'S Sarcoma Of Anus

Kaposi'S Sarcoma Of Central Nervous System

Kaposi'S Sarcoma Of Conjunctiva

Kaposi'S Sarcoma Of Cornea

Kaposi'S Sarcoma Of Esophagus

Kaposi'S Sarcoma Of Gastrointestinal Sites

Kaposi'S Sarcoma Of Heart

Kaposi'S Sarcoma Of Lymph Nodes

Kaposi'S Sarcoma Of Penis

Kaposi'S Sarcoma Of Skin

Kaposi'S Sarcoma Of Soft Tissues

Kaposi'S Sarcoma Of The Cns

Kaposi'S Sarcoma Of The Gallbladder

Kaposi'S Sarcoma Of The Prostate

Kaposi'S Sarcoma, Lung

Kaposi'S Sarcoma, Skin

Lymph Node Kaposi'S Sarcoma

Lymphadenopathic Kaposi'S Sarcoma

Palate Kaposi'S Sarcoma

Penis Kaposi'S Sarcoma

Prostate Kaposi'S Sarcoma

Pulmonary Kaposi'S Sarcoma

Soft Tissue Kaposi'S Sarcoma

Hhv8

Human Herpesvirus 8

Kshv

Kaposi Sarcoma Herpesvirus

Mediterranean Kaposi Sarcoma

Non Aids Related Kaposi Sarcoma

Sarcoma, Kaposi

Sarcoma, Kaposi, Susceptibility To

Non-Aids-Related Kaposi Sarcoma

Angiolymphoid Hyperplasia

Angiofollicular Ganglionic Hyperplasia

Multi-Centric Castleman'S Disease
Autism

Autistic Disorder

Autism Susceptibility 1

Childhood Autism

Autistic Disorder Of Childhood Onset

Infantile Autism

Kanner'S Syndrome

Autistic
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12580 SDC2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris SDC2 VGNC VGNC:54120
Mus musculus SDC2 MGD MGI:1349165
Macaca mulatta SDC2 VGNC VGNC:76998
Felis catus SDC2 VGNC VGNC:64944
Bos taurus SDC2 VGNC VGNC:34379
Rattus norvegicus SDC2 RGD RGD:3649
Others SDC2 NCBI
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