Semaphorin-4A/SEMA4A 蛋白, Human (HEK293, Fc)

Semaphorin-4A/SEMA4A is the cell surface receptor for PLXNB1, PLXNB2, PLXNB3, and PLXND1 and is essential for intercellular signaling. It induces TIMD2 phosphorylation, inhibits angiogenesis, and collapses axonal growth cones. Semaphorin-4A/SEMA4A Protein, Human (HEK293, Fc) is the recombinant human-derived Semaphorin-4A/SEMA4A protein, expressed by HEK293 , with C-hFc labeled tag.

Semaphorin-4A (SEMA4A) 是 PLXNB1、PLXNB2、PLXNB3 和 PLXND1 的细胞表面受体，在细胞间信号传导中发挥着关键作用。这种多面蛋白参与谷氨酸能和 GABA 能突触发育的调节，以 PLXNB1 依赖性方式培育抑制性突触，并以 PLXNB2 依赖性方式培育兴奋性突触。此外，SEMA4A 通过启动抗原特异性 T 细胞、促进 Th1 T 辅助细胞的分化以及促进 TIMD2 的磷酸化来促进适应性免疫。此外，SEMA4A 对血管生成发挥抑制作用，诱导轴突生长锥塌陷，并通过提供指定轴突生长无法到达的区域的局部信号来阻碍轴突延伸。与 PLXNB1、PLXNB2、PLXNB3、PLXND1 和 TIMD2 的相互作用强调了其复杂的作用，强调了其参与多种细胞过程。

Human

HEK293

C-hFc

Q9H3S1-1 (G33-H683)

64218  [NCBI]

Approximately 110 kDa

Greater than 90% as determined by reducing SDS-PAGE

溶液.

Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.