Serpin F1 蛋白, Mouse (375a.a)

Serpin F1 is a neurotrophin that significantly induces extensive neuronal differentiation of retinoblastoma cells and exhibits potent anti-angiogenic effects.Its unique conformation lacks the S (stress) to R (relaxation) transition typical of active serpins, resulting in a lack of serpin activity.Serpin F1 Protein, Mouse is the recombinant mouse-derived Serpin F1 protein, expressed by E.coli , with tag free.

Serpin F1 是一种神经营养蛋白，是视网膜母细胞瘤细胞广泛神经元分化的关键诱导物。值得注意的是，它对血管生成具有有效的抑制作用。以其独特的构象特征而著称，Serpin F1 不会经历活性丝氨酸蛋白酶抑制剂典型的从 S（应激）到 R（松弛）的转变，从而导致缺乏丝氨酸蛋白酶抑制活性。此外，它与 PNPLA2 的相互作用可刺激 PNPLA2 的磷脂酶 A2 活性，强调 Serpin F1 在细胞过程中的多方面作用。

Measured by its ability to enhance the adhesion of Saos‑2 human osteosarcoma cells to bovine Collagen I coated plate. The ED₅₀ for this effect is 0.4644 μg/ml, corresponding to a specific activity is 2.153×10³ units/mg.

Mouse

E. coli

Tag Free

P97298 (D43-T417)

20317  [NCBI]

DPFFKVPVNKLAAAVSNFGYDLYRLRSSASPTGNVLLSPLSVATALSALSLGAEHRTESVIHRALYYDLITNPDIHSTYKELLASVTAPEKNLKSASRIVFERKLRVKSSFVAPLEKSYGTRPRILTGNPRVDLQEINNWVQAQMKGKIARSTREMPSALSILLLGVAYFKGQWVTKFDSRKTTLQDFHLDEDRTVRVPMMSDPKAILRYGLDSDLNCKIAQLPLTGSMSIIFFLPLTVTQNLTMIEESLTSEFIHDIDRELKTIQAVLTVPKLKLSFEGELTKSLQDMKLQSLFESPDFSKITGKPVKLTQVEHRAAFEWNEEGAGSSPSPGLQPVRLTFPLDYHLNQPFLFVLRDTDTGALLFIGRILDPSST

Approximately 40.0 kDa

Greater than 95% as determined by reducing SDS-PAGE.

溶液.

Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.