Serpin A8/Angiotensinogen 蛋白, Human (HEK293, His, solution)

Serpin A8/angiotensinogen protein is an important component of the renin-angiotensin system (RAS), which regulates blood pressure, fluid balance, and electrolyte homeostasis. Serpin A8/Angiotensinogen Protein, Human (HEK293, His, solution) is the recombinant human-derived Serpin A8/Angiotensinogen protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Serpin A8/Angiotensinogen Protein, Human (HEK293, His, solution) is 452 a.a., with molecular weight of 55.0-72.27 kDa.

Serpin A8，也称为血管紧张素原，是肾素-血管紧张素系统 (RAS) 中不可或缺的元素，肾素-血管紧张素系统是控制血压、体液和电解质稳态的有效调节框架。它直接作用于血管平滑肌，产生强大的血管收缩影响，并通过与交感神经系统的相互作用动态影响心肌收缩力和心率。此外，血管紧张素原在塑造肾脏钠和水的吸收方面发挥着关键作用，通过刺激肾上腺皮质中的肾小球带细胞合成和释放醛固酮来发挥其作用。这种多方面的功能是通过血管紧张素原与血管紧张素受体 AGTR1 和 AGTR2 的结合介导的，从而协调一系列的生理反应。除了在 RAS 中的关键作用之外，血管紧张素原还表现出与 DEAR/FBXW7-AS1 受体结合的能力，扩大了其分子相互作用的范围，并对其调节影响提出了更广泛的影响。

Measured in a cell proliferation assay using HT-29 cells. The ED₅₀ for this effect is 54.57 ng/mL, corresponding to a specific activity is 1.833×10⁴ Unit/mg.

Human

HEK293

C-6*His

P01019/AAH11519.1 (D34-A485)

183  [NCBI]

DRVYIHPFHLVIHNESTCEQLAKANAGKPKDPTFIPAPIQAKTSPVDEKALQDQLVLVAAKLDTEDKLRAAMVGMLANFLGFRIYGMHSELWGVVHGATVLSPTAVFGTLASLYLGALDHTADRLQAILGVPWKDKNCTSRLDAHKVLSALQAVQGLLVAQGRADSQAQLLLSTVVGVFTAPGLHLKQPFVQGLALYTPVVLPRSLDFTELDVAAEKIDRFMQAVTGWKTGCSLMGASVDSTLAFNTYVHFQGKMKGFSLLAEPQEFWVDNSTSVSVPMLSGMGTFQHWSDIQDNFSVTQVPFTESACLLLIQPHYASDLDKVEGLTFQQNSLNWMKKLSPRTIHLTMPQLVLQGSYDLQDLLAQAELPAILHTELNLQKLSNDRIRVGEVLNSIFFELEADEREPTESTQQLNKPEVLEVTLNRPFLFAVYDQSATALHFLGRVANPLSTA

55.0-72.27 kDa

Greater than 95% as determined by reducing SDS-PAGE.

溶液.

Supplied as a 0.2 μm filtered solution of 20 mM PB,150 mM NaCl, pH 7.4.

<1 EU/μg, determined by LAL method.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.