Serum Albumin/ALB 蛋白, Cynomolgus (HEK293, His)

Serum Albumin (ALB) protein binds various substances, including water, calcium, sodium, potassium, fatty acids, hormones, bilirubin, and drugs. It regulates blood osmotic pressure and transports zinc, calcium, and magnesium. ALB can interact with zinc and calcium, potentially affecting their transport. It impedes enterobactin-mediated iron uptake by E.coli but not aerobactin-mediated uptake. ALB interacts with FCGRT and TASOR for homeostasis. It forms a complex with alpha-1-microglobulin but doesn't hinder fatty acid binding. Serum Albumin/ALB Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived Serum Albumin/ALB protein, expressed by HEK293, with C-His labeled tag. The total length of Serum Albumin/ALB Protein, Cynomolgus (HEK293, His) is 584 a.a., with molecular weight of 68-70 kDa.

血清白蛋白 (ALB) 蛋白具有多种作用，包括结合水、钙、钠、钾、脂肪酸、激素、胆红素和药物。其主要功能涉及调节血液的胶体渗透压。ALB 是血浆中锌的主要转运蛋白，结合约 80% 的血浆锌。它还作为钙和镁的重要转运蛋白，结合血浆中大约 45% 的循环钙和镁。ALB 可能拥有多个钙结合位点，并且还可以以非特异性方式结合钙。残基 Asp-273 处锌和钙之间存在共享结合位点，表明血液中锌和钙转运之间存在潜在的相互作用和通讯，其中锌表现出更高的亲和力，其次是钙和镁。ALB 还与细菌铁载体肠杆菌素相互作用，阻碍肠杆菌介导的大肠杆菌从铁转铁蛋白中摄取铁，从而限制铁的利用和大肠杆菌等肠道细菌的生长。然而，它不会阻碍细菌铁载体需氧菌素对铁的吸收。ALB 与 FCGRT 相互作用以调节其稳态，并与 TASOR 相互作用。在血浆中，ALB 与发色团结合的 α-1-微球蛋白形成共价连接的复合物，但这种相互作用并不妨碍脂肪酸与 ALB 的结合。

Cynomolgus

HEK293

C-His

A2V9Z4 (D25-A608)

102130757  [NCBI]

68-70 kDa

Greater than 95% as determined by Tris-Bis PAGE.

<1 EU/μg, determined by LAL method.