Serum Albumin/ALB 蛋白, Rabbit (HEK293, His)

ALB protein is a serum protein synthesized by the liver and plays a vital role in maintaining body fluid balance and transporting various molecules in the blood. It is involved in the regulation of osmotic pressure and acts as a carrier for hormones, fatty acids, and drugs. Serum Albumin/ALB Protein, Rabbit (HEK293, His) is the recombinant Rabbit-derived Serum Albumin/ALB protein, expressed by HEK293 , with C-His labeled tag. The total length of Serum Albumin/ALB Protein, Rabbit (HEK293, His) is 584 a.a., with molecular weight of 60-70 kDa.

ALB 蛋白是一种多功能分子，可结合水、Ca(2+)、Na(+)、K(+)、脂肪酸、激素、胆红素和药物。其主要作用是调节血液的胶体渗透压。作为血浆中的主要锌转运蛋白，它结合约 80% 的血浆锌，同时也作为主要的钙和镁转运蛋白，结合血浆中约 45% 的循环钙和镁。ALB 蛋白可能具有多个钙结合位点，并且可能以非特异性方式结合钙。残基 Asp-273 处锌和钙之间的相互作用表明血液中锌和钙转运之间存在串扰。其亲和力顺序为锌>钙>镁。此外，ALB 蛋白与细菌铁载体肠杆菌素相互作用，抑制其铁吸收，并可能限制大肠杆菌等肠道细菌的生长。值得注意的是，它不会阻碍细菌铁载体需氧菌素对铁的吸收。ALB 蛋白还通过与 FCGRT 相互作用在 ALB 稳态中发挥作用，并且还与 TASOR 相互作用。在血浆中，ALB 蛋白与发色团结合的 α-1-微球蛋白形成共价连接的复合物，而不会阻碍脂肪酸与 ALB 的结合。

Rabbit

HEK293

C-His

P49065-1 (E25-G608)

100009195  [NCBI]

60-70 kDa

• 
  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized a 0.22 μm filtered solution of PBS, pH 7.4. Normally trehalose is added as protectant before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.