2. 重组蛋白
  3. Receptor Proteins
  4. Cell Adhesion Molecules (CAMs)
  5. Immunoglobulin-like Cell Adhesion Molecules
  6. Signal Regulatory Protein Beta
  7. SIRP beta 蛋白, Mouse (HEK293, His)

SIRP beta 蛋白, Mouse (HEK293, His)

目录号: HY-P77490
COA 产品使用指南

SIRP- β (Sirpb, CD172b) 是信号调节蛋白 (SIRP) 家族的成员，也属于免疫球蛋白超家族 (IgSF)。SIRP 家族成员是受体型跨膜糖蛋白，Sirpb 被发现与携带免疫受体酪氨酸激活基序的跨膜衔接蛋白 TYROBP/DAP12 相互作用，导致 DAP12 的酪氨酸磷酸化，随后 Syk 被募集到 Sirpb-DAP12 复合体上。Sirpb 还被认为是造血细胞的正调节因子。SIRP beta 蛋白, Mouse (HEK293, His) 是重组的 SIRP β 蛋白，由 HEK293 表达，带有 C-His 标签。

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描述

SIRP-beta (Sirpb, CD172b) is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins, Sirpb was found to interact with TYROBP/DAP12, a transmembrane adaptor protein bearing immunoreceptor tyrosine-based activation motifs, resulting in the tyrosine phosphorylation of DAP12 and the subsequent recruitment of Syk to the Sirpb-DAP12 complex. Sirpb is also implicated as a positive regulator of hematopoietic cells. SIRP beta Protein, Mouse (HEK293, His) is the recombinant mouse-derived SIRP beta protein, expressed by HEK293 , with C-His labeled tag.
研究背景

SIRP- β (Sirpb, CD172b) 是信号调节蛋白 (SIRP) 家族的成员，也属于免疫球蛋白超家族 (IgSF)，其胞外结构域有三个 IgSF 结构域。SIRP 家族成员是受体型跨膜糖蛋白，已知参与受体酪氨酸激酶偶联信号传导过程的负调控。Sirpb 被发现与 TYROBP/DAP12 相互作用，TYROBP/DAP12 是一种携带免疫受体酪氨酸激活基序的跨膜衔接蛋白。在 RBL-2H3 细胞转染物中，Sirpb 的连接导致 DAP12 的酪氨酸磷酸化，随后 Syk 被募集到 Sirpb-DAP12 复合体上。它还刺激了这些细胞的血清素释放。因此，Sirpb 被认为是造血细胞的积极调节因子[1][2]。
种属

Mouse
表达系统

HEK293
标签

C-10*His
蛋白编号

BAD26610 (A27-K363)
基因 ID

/
蛋白结构
N-term
SIRP beta (A27-K363)
Accession # BAD26610
His
C-term
同用名
SIRP-beta B-type; Sirpb1a; SIRP-beta
氨基酸序列

AMRELKVIQPVKSFFVGAGGSATLNCTVTSLLPVGPMRWYRGIGQSRLLIYSFTGEGFPRITNTSDTTKRNNMDFSIRISNVTPADSGTYYCVKFQRGPSDFYTEIQSGGGTELSVLAKPSSPMVSGPAARAVPQQTVTFTCRSHGFFPRNLTLKWFKNGDEISHLETSVEPEETSVSYRVSSTVQVVLEPRDVRSQIICEVDHVTLDRAPLRGIAHISEFIQVPPTLEIRQQPTMVWNVINVTCQIQKFYPPSFQLTWLENGNISRREVPFTLTVNKDGTYNWISCLLVNISALEENMVVTCQVEHDGQAEVIETHTVVVTEHQRVKELKTAGIAK

分子量

Approximately 55-60 kDa due to the glycosylation.
纯度

Greater than 95% as determined by reducing SDS-PAGE
内毒素含量

<0.1 EU/μg, determined by LAL method.
文件资料

COA (147 KB)

产品使用指南 (1213 KB)

SIRP beta Protein, Mouse (HEK293, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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