SLAMF2/CD48 蛋白, Mouse (216a.a, HEK293, Fc)

CD48 (SLAMF2) is a member of the CD2 subfamily of immunoglobulin-like receptors, it is held at the cell surface by a Glycosylphosphatidylinositol GPI anchor via a C-terminal domain, and interacts with cell surface receptors including 2B4/CD244 or CD2 via its N-terminal immunoglobulin domain to activate the LCK pathway and regulate immune cell function and activation. SLAMF2/CD48 Protein, Mouse (216a.a, HEK293, Fc) is the recombinant mouse-derived SLAMF2/CD48 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of SLAMF2/CD48 Protein, Mouse (216a.a, HEK293, Fc) is 216 a.a., with molecular weight of ~63.7 kDa.

CD48 (SLAMF2) 是免疫球蛋白样受体 CD2 亚家族的成员，包括 SLAM (信号淋巴细胞激活分子) 蛋白。CD48存在于淋巴细胞等免疫细胞、树突状细胞和内皮细胞的表面，参与这些细胞的活化和分化途径。
CD48 没有跨膜结构域，通过 C 端结构域被糖基磷脂酰肌醇 (GPI) 锚定在细胞表面，该结构域可能被裂解产生可溶性形式的受体，而 CD48 通过其 N 端免疫球蛋白结构域与包括 2B4/CD244 或 CD2 的细胞表面受体相互作用，以调节免疫细胞的功能和激活。
CD48 通过与 CD2 结合参与 T 细胞信号转导，并有效地将 Src 家族蛋白激酶 LCK 和 LAT 带入 TCR/CD3 复合体，进而促进 LCK 磷酸化和随后的激活。
CD48 还诱导 CD244 的胞质免疫受体酪氨酸开关基序 (ITSMs) 的磷酸化，启动一系列信号事件，导致免疫突触的产生，使 T 淋巴细胞和 NK 细胞定向释放含有穿孔素和颗粒酶的细胞溶解颗粒^[1][2][3]。

Mouse

HEK293

C-hFc

BAE96326 (M1-R216)

12506  [NCBI]

Approximately 63.7 kDa

Greater than 90% as determined by reducing SDS-PAGE

<1 EU/μg, determined by LAL method.