SLC40A1 蛋白, Human (Sf9, His, MBP, FLAG)

SLC40A1 plays a pivotal role in systemic iron homeostasis by transporting Fe(2+) from cells to the bloodstream. Essential for maintaining iron balance, it enables dietary iron uptake, recycling by macrophages and erythrocytes, and controlled release from hepatocytes. In iron surplus, elevated HAMP/hepcidin levels prompt SLC40A1 degradation, limiting iron efflux into the plasma. SLC40A1 Protein, Human (Sf9, His, MBP, FLAG) is the recombinant human-derived SLC40A1 protein, expressed by Sf9 insect cells , with N-MBP, C-Flag, N-8*His labeled tag. The total length of SLC40A1 Protein, Human (Sf9, His, MBP, FLAG) is 570 a.a., .

SLC40A1 通过协调 Fe(2+) 从细胞内环境到细胞外空间的运输，成为全身铁稳态的关键参与者。SLC40A1 在维持铁水平的微妙平衡方面发挥着核心作用，可促进铁从各种细胞类型（包括肠细胞、脾细胞、肝细胞、巨噬细胞和红细胞）转移到血液中，确保铁向各种组织的稳定供应（通过相似性）。这种多方面的蛋白质控制着重要的过程，例如膳食铁的吸收、巨噬细胞和红细胞对铁的再循环，以及肝细胞中铁储存的受控释放（通过相似性）。值得注意的是，在血清铁过剩的情况下，循环 HAMP/铁调素水平升高会促使 SLC40A1 降解，从而限制铁流入血浆。

Human

Sf9 insect cells

N-MBP;C-Flag;N-8*His

Q9NP59 (T2-V571)

30061

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.