SMR3B 蛋白, Human (HEK293, His)

SMR3B Protein is an important oncogenic driver that promotes cancer progression and metastasis. SMR3B overexpression in multiple cancers has pleiotropic effects, causing cells to acquire hallmark traits such as sustained proliferative signaling, replicative immortality, genome instability and mutation, resistance to cell death, angiogenesis etc. In addition, up-regulation of SMR3B activates the Src kinase, which initiates a number of signal pathways culminating in the phosphorylation of ERK1/2, STAT3, and p130. SMR3B Protein, Human (HEK293, His) is the recombinant human-derived SMR3B protein, expressed by HEK293 , with C-His labeled tag. The total length of SMR3B Protein, Human (HEK293, His) is 79 a.a., with molecular weight of ~8 kDa.

颌下腺雄激素调节蛋白 3B (SMR3B) 是促进癌症进展和转移的重要致癌驱动因素。SMR3B 在多种癌症中过度表达具有多效性，导致细胞获得标志性特征，如持续增殖信号、复制永生、基因组不稳定和突变、细胞死亡抵抗、血管生成等。此外，SMR3B 的上调可激活 Src 激酶，它启动许多信号通路，最终导致 ERK1/2、STAT3 和 p130 的磷酸化。重要的是，它在广泛的癌症中的肿瘤特异性表达和在正常组织中的缺失使其成为一个有吸引力的靶点^[1][2]。

Human

HEK293

C-6*His

P02814/NP_006676.1 (Q23-P79)

10879  [NCBI]

QRGPRGPYPPGPLAPPQPFGPGFVPPPPPPPYGPGRIPPPPPAPYGPGIFPPPPPQP

Approximately 9 kDa

Greater than 95% as determined by reducing SDS-PAGE

无菌粉末.

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4, 8% trehalose.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.