SNCG 蛋白, Human

SNCG proteins help maintain the integrity of neurofilament networks and may influence axonal structure during development and adulthood. In vitro, it enhances the sensitivity of neurofilament-H to calcium-dependent proteases. SNCG Protein, Human is the recombinant human-derived SNCG protein, expressed by E. coli , with tag free. The total length of SNCG Protein, Human is 127 a.a., with molecular weight of 16-18 kDa.

SNCG 蛋白在维持神经丝网络完整性方面发挥着至关重要的作用，表明在发育阶段和成年期参与塑造轴突结构。此外，它可能有助于调节皮肤中的角蛋白网络。体外研究表明 SNCG 增加神经丝 H 对钙依赖性蛋白酶的敏感性，这意味着 SNCG 在调节神经丝动力学中发挥作用。此外，SNCG 激活 MAPK 和 Elk-1 信号转导通路，并表现出潜在的中心体关联。它与 MYOC 的相互作用影响 MYOC 的分泌和聚集，突显 SNCG 广泛参与细胞过程，并对神经元和皮肤相关功能产生影响。

Measured by its binding ability in a functional ELISA. When Recombinant Human SNCG is immobilized at 2.5 µg/mL(100 µL/well) can bind Anti-SNCG. The ED₅₀ for this effect is 147.1 ng/mL.

Human

E. coli

Tag Free

O76070 (M1-D127)

6623  [NCBI]

MDVFKKGFSIAKEGVVGAVEKTKQGVTEAAEKTKEGVMYVGAKTKENVVQSVTSVAEKTKEQANAVSEAVVSSVNTVATKTVEEAENIAVTSGVVRKEDLRPSAPQQEGEASKEKEEVAEEAQSGGD

Approximately 16-18 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4 or PBS, pH 7.4, 8% trehalose.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.