Sphingomyelin Synthase 2/SGMS2 蛋白, Human (HEK293, Fc)

The sphingomyelin synthase 2 (SGMS2) protein plays a crucial role in plasma membrane sphingomyelin synthesis. It catalyzes the reversible transfer of the phosphocholine moiety in sphingomyelin biosynthesis to form ceramide phosphocholine. Sphingomyelin Synthase 2/SGMS2 Protein, Human (HEK293, Fc) is the recombinant human-derived Sphingomyelin Synthase 2/SGMS2 protein, expressed by HEK293 , with N-mFc labeled tag. The total length of Sphingomyelin Synthase 2/SGMS2 Protein, Human (HEK293, Fc) is 79 a.a., with molecular weight of ~35.7 kDa.

鞘磷脂合酶 2 (SGMS2) 蛋白是质膜鞘磷脂合成和维持的关键贡献者。该酶促进鞘磷脂生物合成中磷酸胆碱部分的可逆转移，催化磷脂酰胆碱和神经酰胺形成神经酰胺磷酸胆碱（鞘磷脂）。该反应的方向受质膜中神经酰胺和二酰甘油水平的影响。此外，SGMS2可以将磷脂酰乙醇胺的磷酸乙醇胺头基转移到神经酰胺上，生成神经酰胺磷酸乙醇胺。除了在鞘脂代谢中的作用之外，SGMS2 通过调节二酰甘油和神经酰胺水平来调节受体介导的信号转导，影响促有丝分裂和促凋亡信号传导。此外，SGMS2 有助于分泌运输并影响高尔基体功能，特别是影响 PRKD1 的下游效应。它参与这些细胞过程凸显了其在维持膜结构、调节信号转导和影响骨基质矿化方面的重要性。

The enzyme activity of this recombinant protein is testing in progress, we cannot offer a guarantee yet.

Human

HEK293

N-mFc

Q8NHU3 (M1-T79)

166929  [NCBI]

MDIIETAKLEEHLENQPSDPTNTYARPAEPVEEENKNGNGKPKSLSSGLRKGTKKYPDYIQIAMPTESRNKFPLEWWKT

Approximately 35.7 kDa

• 
  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.