Stabilin-2 蛋白, Human (His)

Stabilin-2 protein is a multifunctional phosphatidylserine and hyaluronic acid receptor that engulfs apoptotic cells and mediates hyaluronic acid endocytosis. As a systemic scavenger receptor, it binds various ligands and supports extracellular matrix turnover and body mobility. Stabilin-2 Protein, Human (His) is the recombinant human-derived Stabilin-2 protein, expressed by E. coli , with C-His labeled tag.

Stabilin-2 蛋白作为多功能磷脂酰丝氨酸受体，促进凋亡细胞的吞噬，并作为透明质酸受体发挥作用，介导透明质酸 (HA) 的内吞作用。此外，它还充当主要的全身清道夫受体，与各种配体结合，例如肝素、硫酸软骨素、硫酸皮肤素、非糖胺聚糖分子、乙酰化低密度脂蛋白、前胶原前肽和高级糖基化终产物。Stabilin-2 可能通过支持细胞外基质更新在维持组织完整性方面发挥关键作用，并通过吸收透明质酸促进体液的流动性。该受体还充当反受体，促进肝血管系统中淋巴细胞的募集，并表现出结合革兰氏阳性和革兰氏阴性细菌的能力，可能在防御细菌感染中发挥作用。经过蛋白水解处理的 190 kDa 形式的 Stabilin-2 可作为肝素内化、透明质酸和硫酸软骨素的内吞受体。与 GULP1、肝素、α-M/β-2 整合素和胸腺肽 β 4 的相互作用进一步强调了 Stabilin-2 的多种功能。

Measured by its binding ability in a functional ELISA. Immobilized Recombinant Human Stabilin-2 at 2 μg/mL bind biotinylated Hyaluronan. The ED₅₀ for this effect is 0.09732 nM.

Human

E. coli

C-6*His

Q8WWQ8 (G2198-V2295)

55576  [NCBI]

GVFHLRSPLGQYKLTFDKAREACANEAATMATYNQLSYAQKAKYHLCSAGWLETGRVAYPTAFASQNCGSGVVGIVDYGPRPNKSEMWDVFCYRMKDV

Approximately 12 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4, 8% trehalose.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.