STAB2 - stabilin 2 Gene

中文名称：稳定素 2

种属: Homo sapiens

同用名: FEX2; HARE; FEEL2; FELL2; FELE-2; SCARH1

关于 STAB2

功能概要

该基因编码一种大的跨膜受体蛋白，该蛋白可能在血管生成、淋巴细胞归巢、细胞粘附或受体清除中发挥作用。该蛋白质包含 7 个成束蛋白、15 个表皮生长因子 (EGF) 样结构域和 2 个层粘连蛋白型 EGF 样结构域以及一个 C 型凝集素样透明质酸结合连接模块。该蛋白主要在肝、脾和淋巴结的窦状内皮细胞上表达。该受体已被证明可以结合和内吞配体，例如透明质酸、低密度脂蛋白、革兰氏阳性和革兰氏阴性细菌，以及高级糖基化终产物。支持其作为清道夫受体的可能作用，该蛋白质已被证明在质膜和溶酶体之间循环。[RefSeq 提供，2008 年 7 月]

This gene encodes a large, transmembrane receptor protein which may function in angiogenesis, lymphocyte homing, cell adhesion, or receptor scavenging. The protein contains 7 fasciclin, 15 epidermal growth factor (EGF)-like, and 2 laminin-type EGF-like domains as well as a C-type lectin-like hyaluronan-binding Link module. The protein is primarily expressed on sinusoidal endothelial cells of liver, spleen, and lymph node. The receptor has been shown to bind and endocytose ligands such as hyaluronan, low density lipoprotein, Gram-positive and Gram-negative bacteria, and advanced glycosylation end products. Supporting its possible role as a scavenger receptor, the protein has been shown to cycle between the plasma membrane and lysosomes. [provided by RefSeq, Jul 2008]