STAT3 蛋白, Human (His)

STAT3 is a signal transducer and transcriptional activator that coordinates diverse cellular processes in response to growth factors and cytokines such as interleukin-6 and KITLG/SCF. Upon activation, STAT3 recruits coactivators to target gene promoters, thereby affecting proliferation, differentiation, and immune responses. STAT3 Protein, Human (His) is the recombinant human-derived STAT3 protein, expressed by E. coli , with C-6*His labeled tag. The total length of STAT3 Protein, Human (His) is 175 a.a., with molecular weight of 19 & 46 kDa, respectively.

STAT3 是一种信号转导器和转录激活剂，协调细胞对各种生长因子、白细胞介素和细胞因子的反应。激活后，STAT3 将共激活子招募到靶基因的启动子区域，从而介导多种细胞过程，例如增殖、分化和免疫反应调节。它对白细胞介素 6、KITLG/SCF 和其他生长因子的信号作出反应，促进一系列下游事件。此外，STAT3 在细胞周期调节、炎症反应调节和能量稳态中发挥作用。其功能延伸至影响细胞凋亡、黑皮质素产生和胰岛素分泌。蛋白质的激活涉及与相关家族成员的同二聚化或异二聚化。STAT3 与一系列分子相互作用，包括 IL31RA、NCOA1、PELP1、SIPAR、SOCS7、STATIP1 等，使其复杂地参与细胞信号传导通路。

Human

E. coli

C-6*His

P40763 (M1-N175)

6774  [NCBI]

MAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAYAASKESHATLVFHNLLGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWEESRLLQTAATAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFN

20&47 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4 or 20mM Tris-HCl, 10% Trehalose, 50mM NaCl, 0.05% Tween 80, pH 8.0.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US;may vary elsewhere.